Cancer is the leading disease-related cause of death in children in developed countries.
Arising in the context of actively growing tissues, childhood cancers are fundamentally …

The development of effective treatment strategies for most forms of acute myeloid leukemia
(AML) has languished for the past several decades. There are a number of reasons for this …

Multiple new drugs are being developed to treat acute myeloid leukemia (AML), including
novel formulations of traditional chemotherapy-antibody drug conjugates and agents that …

Recent studies of the spectrum of somatic genetic alterations in acute myeloid leukemia
(AML) have identified frequent somatic mutations in genes that encode proteins important in …

The most frequently mutated metabolic genes in human cancer are those encoding the
enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been …

Early immature T cell acute lymphoblastic leukemias (T-ALLs) account for∼ 5–10% of
pediatric T-ALLs and are associated with poor prognosis. However, the genetic defects that …

The genetic basis of leukemogenesis in adults with B-cell acute lymphoblastic leukemia (B-
ALL) is largely unclear, and its clinical outcome remains unsatisfactory. This study aimed to …

Isocitrate dehydrogenases play important roles in cellular metabolism and cancer. This
review will discuss how the roles of isoforms 1 and 2 in normal cell and cancer metabolism …

Isocitrate dehydrogenase (IDH) is a reversible enzyme that catalyzes the NADP+-dependent
oxidative decarboxylation of isocitrate (ICT) to α-ketoglutarate (αKG) and the NADPH/CO 2 …

Adult T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor
associated with poor outcome. In this study, we analyzed the prognostic relevance of genetic …