Substantial progress in understanding T cell signalling, particularly with respect to T cell co-
receptors such as the co-stimulatory receptor CD28, has been made in recent years. This …

Ovarian cancer is a common gynecological malignancy, and its treatment remains
challenging. Although ovarian cancer may respond to immunotherapy because of …

PD-1+ TCF-1+ stem-like CD8 T cells act as critical resource cells for maintaining T cell
immunity in chronic viral infections and cancer. In addition, they provide the proliferative …

Successful immunotherapy relies on triggering complex responses involving T cell dynamics
in tumors and the periphery. Characterizing these responses remains challenging using …

Immune responses must be tightly regulated to ensure both optimal protective immunity and
tolerance. Costimulatory pathways within the B7: CD28 family provide essential signals for …

CD8+ T cells are the workhorses executing adaptive anti-tumour response, and targets of
various cancer immunotherapies. Latest advances have unearthed the sheer heterogeneity …

The maintenance of antigen-specific CD8+ T cells underlies the efficacy of vaccines and
immunotherapies. Pathways contributing to CD8+ T cell loss are not completely understood …

Inhibiting T cell exhaustion is an attractive cancer immunotherapy strategy. In this issue of
Immunity, Waibl Polania et al. examine the microenvironmental signals regulating terminal T …

This study examines the origin and differentiation of stem-like CD8+ T cells that are essential
for sustained T cell immunity in chronic viral infections and cancer and also play a key role in …

CD8+ cytotoxic T lymphocytes (CTLs) are central mediators of tumor immunity and
immunotherapies. Upon tumor antigen recognition, CTLs differentiate from naive/memory …