Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …

Therapeutic approaches to the treatment of type 2 diabetes mellitus that are designed to
increase insulin secretion either directly target β-cells or indirectly target gastrointestinal …

Primary cilia are specialized cell-surface organelles that mediate sensory perception and, in
contrast to motile cilia and flagella, are thought to lack motility function. Here, we show that …

Since the discovery of glucagon 100 years ago, the hormone, and the pancreatic islet alpha
cells that produce it, have remained enigmatic relative to insulin producing beta cells …

Human islet primary cilia are vital glucose-regulating organelles whose structure remains
uncharacterized. Scanning electron microscopy (SEM) is a useful technique for studying the …

Primary cilia are specialized organelles that sense changes in extracellular milieu, and their
malfunction is responsible for several disorders (ciliopathies). Increasing evidence shows …

The primary cilium is a nexus for cell signaling and relies on specific protein trafficking for
function. The tubby family protein TULP3 transports integral membrane proteins into cilia …

The primary cilium is a microtubule-based cellular protrusion found on most mammalian cell
types in diverse tissues. It functions as a cellular antenna to sense and transduce a broad …

Somatostatin is a paracrine modulator of insulin secretion and beta cell function with
pleotropic effects on glucose homeostasis. The mechanism of somatostatin-mediated …

Primary cilia are slender cell-surface organelles that project into the intercellular space. In
pancreatic beta cells, primary cilia coordinate a variety of cell responses including GPCR …