High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

F Böttger, A Vallés-Martí, L Cahn… - Journal of experimental & …, 2021 - Springer
Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …

Targeting cancer vulnerabilities with high-dose vitamin C

B Ngo, JM Van Riper, LC Cantley, J Yun - Nature Reviews Cancer, 2019 - nature.com
Over the past century, the notion that vitamin C can be used to treat cancer has generated
much controversy. However, new knowledge regarding the pharmacokinetic properties of …

Drug repurposing for cancer therapy

Y Xia, M Sun, H Huang, WL Jin - Signal Transduction and Targeted …, 2024 - nature.com
Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …

Intravenous vitamin C for cancer therapy–identifying the current gaps in our knowledge

AC Carr, J Cook - Frontiers in physiology, 2018 - frontiersin.org
The use of intravenous vitamin C (IVC) for cancer therapy has long been an area of intense
controversy. Despite this, high dose IVC has been administered for decades by …

Signal pathway of estrogen and estrogen receptor in the development of thyroid cancer

J Liu, T Xu, L Ma, W Chang - Frontiers in oncology, 2021 - frontiersin.org
The molecular mechanisms underlying the development of thyroid cancer (TC) have been
examined through extensive experiments. A large number of studies have shown that the …

High-dose vitamin C for cancer therapy

A Mussa, RA Mohd Idris, N Ahmed, S Ahmad… - Pharmaceuticals, 2022 - mdpi.com
In recent years, the idea that Vitamin C (Vit-C) could be utilized as a form of anti-cancer
therapy has generated many contradictory arguments. Recent insights into the physiological …

Lipophilic and Hydrophilic Compounds from Arthrospira platensis and Its Effects on Tissue and Blood Cells—An Overview

F Jung, S Braune, CHG Jung, A Krüger-Genge… - Life, 2022 - mdpi.com
The cyanobacterium Arthrospira platensis (Spirulina platensis) is a natural source of
considerable amounts of ingredients that are relevant for nutra-and pharmaceutical uses …

Role of vitamins A, C, D, E in cancer prevention and therapy: Therapeutic potentials and mechanisms of action

WH Talib, DA Ahmed Jum'AH, ZS Attallah… - Frontiers in …, 2024 - frontiersin.org
Cancer, a leading global cause of mortality, arises from intricate interactions between
genetic and environmental factors, fueling uncontrolled cell growth. Amidst existing …

Oncometabolic role of mitochondrial sirtuins in glioma patients

MFU Haq, MZ Hussain, I Mahjabeen, Z Akram… - PloS one, 2023 - journals.plos.org
Mitochondrial sirtuins have diverse role specifically in aging, metabolism and cancer. In
cancer, these sirtuins play dichotomous role as tumor suppressor and promoter. Previous …

Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine

RLI Crake, ER Burgess, GAR Wiggins, NJ Magon… - Scientific Reports, 2022 - nature.com
Gliomas are incurable brain cancers with poor prognosis, with epigenetic dysregulation
being a distinctive feature. 5-hydroxymethylcytosine (5-hmC), an intermediate generated in …