The blood-brain barrier (BBB) constitutes a microvascular network responsible for excluding
most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the …

The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy
critical to neuronal function while simultaneously excluding neurotoxic substances from the …

Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …

The blood–brain barrier (BBB) is a highly regulated and efficient barrier that provides a
sanctuary to the brain. It is designed to regulate brain homeostasis and to permit selective …

Gliomas are the most common primary brain tumors. Particularly in adult patients, the vast
majority of gliomas belongs to the heterogeneous group of diffuse gliomas, ie. glial tumors …

Peptide-based strategies have received an enormous amount of attention because of their
specificity and applicability. Their specificity and tumor-targeting ability are applied to …

Over the past decade, we have made considerable progress in establishing diffuse intrinsic
pontine glioma (DIPG) as a disease entity and developing preclinical tools to interrogate …

The blood brain barrier (BBB) represents a major obstacle for targeted drug delivery to the
brain for the treatment of central nervous system (CNS) disorders. Significant advances in …

Despite scientific advances in understanding the causes and treatment of human
malignancy, a persistent challenge facing basic and clinical investigators is how to …

Diffuse intrinsic pontine gliomas (DIPGs) are amongst the most challenging tumors to treat.
Surgery is not an option, the effects of radiation therapy are temporary, and no …