Intraportal islet transplantation has proven to be efficacious in preventing severe
hypoglycemia and restoring insulin independence in selected patients with type 1 diabetes …

Diabetes is a major health issue of increasing prevalence. ß‐cell replacement, by pancreas
or islet transplantation, is the only long‐term curative option for patients with insulin …

In recent years, significant breakthroughs have been made in the field of gene therapy.
Adeno-associated virus (AAV) is one of the most promising gene therapy vectors and a …

Improving healthspan is the main objective of anti-ageing research. Currently, innovative
gene therapy-based approaches seem to be among the most promising for preventing and …

The discovery of insulin a century ago changed the lives of millions of individuals suffering
from diabetes, paving the way for long-term survival. While the availability of recombinant …

Background Diabetes mellitus is caused by a partial or complete lack of insulin production in
the body. We have previously shown that a single injection of an adeno‐associated virus …

Adeno-associated viruses (AAVs) have emerged as promising tools for gene therapy due to
their safety and efficacy in delivering therapeutic genes or gene editing sequences to …

Synthetic riboswitches that can regulate gene expression by a small molecule recognized by
an RNA aptamer in mammalian cells have various potential applications in biotechnology …

The only treatment tested for growth hormone receptor (GHR) defective Laron Syndrome
(LS) is injections of recombinant insulin-like-growth factor 1 (rhIGF1). The response is …

We have previously used a hepatotropic adeno-associated viral (AAV) vector with a
modified human insulin gene to treat diabetic mice. The HLP (hybrid liver-specific promoter) …