Inflammation-induced DNA damage, mutations and cancer

J Kay, E Thadhani, L Samson, B Engelward - DNA repair, 2019 - Elsevier
The relationships between inflammation and cancer are varied and complex. An important
connection linking inflammation to cancer development is DNA damage. During …

Asia–Pacific Working Party on Non‐alcoholic Fatty Liver Disease guidelines 2017—part 1: definition, risk factors and assessment

VWS Wong, WK Chan, S Chitturi… - Journal of …, 2018 - Wiley Online Library
Since the publication of the guidelines for the assessment and management of non alcoholic
fatty liver disease (NAFLD) by the Asia–Pacific Working Party on NAFLD in 2007, 1 our …

Molecular mechanisms driving progression of liver cirrhosis towards hepatocellular carcinoma in chronic hepatitis B and C infections: a review

T Kanda, T Goto, Y Hirotsu, M Moriyama… - International journal of …, 2019 - mdpi.com
Almost all patients with hepatocellular carcinoma (HCC), a major type of primary liver
cancer, also have liver cirrhosis, the severity of which hampers effective treatment for HCC …

NAFLD, NASH and liver cancer

GA Michelotti, MV Machado, AM Diehl - … reviews Gastroenterology & …, 2013 - nature.com
NAFLD affects a large proportion of the US population and its incidence and prevalence are
increasing to epidemic proportions around the world. As with other liver diseases that cause …

Mitochondrial VDAC1: a key gatekeeper as potential therapeutic target

AKS Camara, YF Zhou, PC Wen, E Tajkhorshid… - Frontiers in …, 2017 - frontiersin.org
Mitochondria are the key source of ATP that fuels cellular functions, and they are also central
in cellular signaling, cell division and apoptosis. Dysfunction of mitochondria has been …

Association between sustained virological response and all-cause mortality among patients with chronic hepatitis C and advanced hepatic fibrosis

AJ Van Der Meer, BJ Veldt, JJ Feld, H Wedemeyer… - Jama, 2012 - jamanetwork.com
Context Chronic hepatitis C virus (HCV) infection outcomes include liver failure,
hepatocellular carcinoma (HCC), and liver-related death. Objective To assess the …

[PDF][PDF] Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection

BQ Starley, CJ Calcagno, SA Harrison - Hepatology, 2010 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a common and deadly malignancy that is increasing in
incidence in developed countries. The emergence of hepatitis C virus (HCV) accounts for …

Hepatocellular carcinoma: epidemiology and molecular carcinogenesis

HB El–Serag, KL Rudolph - Gastroenterology, 2007 - Elsevier
Primary liver cancer, which consists predominantly of hepatocellular carcinoma (HCC), is
the fifth most common cancer worldwide and the third most common cause of cancer …

Hepatocellular carcinoma in cirrhosis: incidence and risk factors

G Fattovich, T Stroffolini, I Zagni, F Donato - Gastroenterology, 2004 - Elsevier
Emerging data indicate that the mortality rate of hepatocellular carcinoma (HCC) associated
with cirrhosis is rising in some developed countries, whereas mortality from non-HCC …

[PDF][PDF] Metabolic syndrome increases the risk of primary liver cancer in the United States: a study in the SEER‐Medicare database

TM Welzel, BI Graubard, S Zeuzem, HB El‐Serag… - …, 2011 - Wiley Online Library
Incidence rates of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma
(ICC) have increased in the United States. Metabolic syndrome is recognized as a risk factor …