How I treat relapsed acute lymphoblastic leukemia in the pediatric population

SP Hunger, EA Raetz - Blood, The Journal of the American …, 2020 - ashpublications.org
Relapsed acute lymphoblastic leukemia (ALL) has remained challenging to treat in children,
with survival rates lagging well behind those observed at initial diagnosis. Although there …

[HTML][HTML] Comprehensive overview of gene rearrangements in childhood T-cell acute lymphoblastic leukaemia

A Mroczek, J Zawitkowska, J Kowalczyk… - International Journal of …, 2021 - mdpi.com
Acute lymphoblastic leukaemia (ALL) is a relevant form of childhood neoplasm, as it
accounts for over 80% of all leukaemia cases. T-cell ALL constitutes a genetically …

Tyrosine kinase inhibitor response of ABL-class acute lymphoblastic leukemia: the role of kinase type and SH3 domain

I van Outersterp, SK Tasian, CEJ Reichert, A Boeree… - Blood, 2024 - ashpublications.org
Acute lymphoblastic leukemia (ALL) with fusions of ABL-class tyrosine kinase genes other
than BCR:: ABL1 occurs in∼ 3% of children with ALL. The tyrosine kinase genes involved in …

[HTML][HTML] Genomic and clinical findings in myeloid neoplasms with PDGFRB rearrangement

D Di Giacomo, M Quintini, V Pierini, F Pellanera… - Annals of …, 2022 - Springer
Platelet-derived growth factor receptor B (PDGFRB) gene rearrangements define a unique
subgroup of myeloid and lymphoid neoplasms frequently associated with eosinophilia and …

[HTML][HTML] Knockdown of AGGF1 inhibits the invasion and migration of gastric cancer via epithelial–mesenchymal transition through Wnt/β-catenin pathway

HH Yao, YJ Zhao, YF He, DB Huang, W Wang - Cancer Cell International, 2019 - Springer
Background Angiogenic factor with G-patch and FHA domain 1 (AGGF1), as a newly
identified human angiogenic factor, is overexpressed in some types of malignant tumors and …

[HTML][HTML] Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma

S De Coninck, R De Smedt, B Lintermans… - …, 2024 - ncbi.nlm.nih.gov
T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) are
rare aggressive hematologic malignancies. Current treatment consists of intensive …

[HTML][HTML] Deregulated expression of NKL homeobox genes in T-cell lymphomas

S Nagel, C Pommerenke, RAF MacLeod, C Meyer… - Oncotarget, 2019 - ncbi.nlm.nih.gov
Recently, we have presented a scheme, termed “NKL-code”, which describes physiological
expression patterns of NKL homeobox genes in early hematopoiesis and in lymphopoiesis …

FHA domain of AGGF1 is essential for its nucleocytoplasmic transport and angiogenesis

CF Zhang, HM Wang, A Wu, Y Li, XL Tian - Science China Life Sciences, 2021 - Springer
Angiogenic factor with G-patch and FHA domains 1 (AGGF1) exhibits a dynamic distribution
from the nucleus to the cytoplasm in endothelial cells during angiogenesis, but the biological …

Delineation of features, responses, outcomes, and prognostic factors in pediatric PDGFRB‐positive acute lymphoblastic leukemia patients: A retrospective multicenter …

X Zhang, Y Wang, X Tian, L Sun, H Jiang, J Chu… - Cancer - Wiley Online Library
Background PDGFRB fusions in acute lymphoblastic leukemia (ALL) is rare. The authors
identified 28 pediatric PDGFRB‐positive ALL. They analyzed the features, outcomes, and …

[PDF][PDF] AGGF1 在乳腺癌中的表达与预后的关系

王波, 董小林 - 临床与病理杂志, 2019 - cdn.amegroups.cn
目的: 探讨AGGF1 (angiogenic factor with G and FHA domains 1) 在乳腺癌中的表达及其与
乳腺癌患者预后的意义. 方法: 利用免疫组织化学方法检测110 例乳腺癌组织及配对癌旁正常 …