Use of defined TLR ligands as adjuvants within human vaccines

MS Duthie, HP Windish, CB Fox… - Immunological …, 2011 - Wiley Online Library
Our improved understanding of how innate immune responses can be initiated and how
they can shape adaptive B‐and T‐cell responses is having a significant impact on vaccine …

Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant

CR Casella, TC Mitchell - Cellular and molecular life sciences, 2008 - Springer
The development of non-infectious subunit vaccines greatly increases the safety of
prophylactic immunization, but also reinforces the need for a new generation of …

Kinetoplastids: related protozoan pathogens, different diseases

K Stuart, R Brun, S Croft, A Fairlamb… - The Journal of …, 2008 - Am Soc Clin Investig
Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma
and Leishmania, which are human pathogens with devastating health and economic effects …

A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing

WW Zhang, S Karmakar, S Gannavaram, R Dey… - Nature …, 2020 - nature.com
Leishmaniasis is a neglected tropical disease caused by Leishmania protozoa transmitted
by infected sand flies. Vaccination through leishmanization with live Leishmania major has …

Current status on prevention and treatment of canine leishmaniasis

RM Reguera, M Moran, Y Perez-Pertejo… - Veterinary …, 2016 - Elsevier
Canine leishmaniasis (CanL) is a parasite-borne disease mainly induced by Leishmania
infantum in the Old World and Leishmania chagasi (infantum) in the New World. CanL is a …

Second-generation vaccines against leishmaniasis

RN Coler, SG Reed - Trends in parasitology, 2005 - cell.com
Several species of Leishmania cause human diseases that range from self-healing
cutaneous lesions to fatal visceral leishmaniasis, mucosal leishmaniasis and diffuse …

Vaccines for leishmaniasis in the fore coming 25 years

CB Palatnik-de-Sousa - Vaccine, 2008 - Elsevier
Human vaccination against leishmaniasis using live Leishmania was used in Middle East
and Russia (1941–1980). First-generation vaccines, composed by killed parasites induce …

From mouse to man: safety, immunogenicity and efficacy of a candidate leishmaniasis vaccine LEISH‐F3+ GLA‐SE

RN Coler, MS Duthie, KA Hofmeyer… - Clinical & …, 2015 - Wiley Online Library
Key antigens of Leishmania species identified in the context of host responses in
Leishmania‐exposed individuals from disease‐endemic areas were prioritized for the …

Vaccine candidates for leishmaniasis: a review

R Nagill, S Kaur - International immunopharmacology, 2011 - Elsevier
Leishmaniasis is a diverse group of clinical syndromes caused by protozoan parasites of the
genus Leishmania. The clinical manifestation of the disease varies from self-limiting …

Vaccines to combat the neglected tropical diseases

JM Bethony, RN Cole, X Guo, S Kamhawi… - Immunological …, 2011 - Wiley Online Library
The neglected tropical diseases (NTDs) represent a group of parasitic and related infectious
diseases such as amebiasis, Chagas disease, cysticercosis, echinococcosis, hookworm …