RNA-binding proteins (RBPs) are essential for the development and function of the immune
system. They interact dynamically with RNA to control its biogenesis and turnover by …

It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play
key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in …

Mitochondrial fission and selective mitochondrial autophagy (mitophagy) form an essential
axis of mitochondrial quality control that plays a critical role in the development of cardiac …

The Notch signaling pathway comprises multiple ligands that are used in distinct biological
contexts. In principle, different ligands could activate distinct target programs in signal …

Acute myeloid leukemia (AML) is a heterogeneous disease caused by a variety of
alterations in transcription factors, epigenetic regulators and signaling molecules. To …

The phosphorylation status of oncoproteins is regulated by both kinases and phosphatases.
Kinase inhibitors are rarely sufficient for successful cancer treatment, and phosphatases …

Metastatic disease represents the major cause of death in oncologic patients worldwide.
Accumulating evidence have highlighted the relevance of a small population of cancer cells …

Our group has reported previously on the role of various members of the protein arginine
methyltransferase (PRMT) family, which are involved in epigenetic regulation, in the …

Whilst it is recognised that targeting self-renewal is an effective way to functionally impair the
quiescent leukaemic stem cells (LSC) that persist as residual disease in chronic myeloid …

Chronic myeloid leukemia (CML) is the best example of successful targeted therapy. Today,
the overall survival of patients with CML treated by using tyrosine kinase inhibitors (TKIs) is …