Causes and consequences of innate immune dysfunction in cirrhosis

KM Irvine, I Ratnasekera, EE Powell… - Frontiers in …, 2019 - frontiersin.org
Liver cirrhosis is an increasing health burden and public health concern. Regardless of
etiology, patients with cirrhosis are at risk of a range of life-threatening complications …

Immune dysfunction and infections in patients with cirrhosis

AR Bonnel, C Bunchorntavakul, KR Reddy - Clinical gastroenterology and …, 2011 - Elsevier
Patients with cirrhosis are immunocompromised and susceptible to infections. Although
detection and treatment of spontaneous bacterial peritonitis (SBP) have improved, overall …

The effect of long-term macrolide treatment on respiratory microbiota composition in non-cystic fibrosis bronchiectasis: an analysis from the randomised, double-blind …

GB Rogers, KD Bruce, ML Martin, LD Burr… - The lancet Respiratory …, 2014 - thelancet.com
Background Long-term macrolide treatment has proven benefit in inflammatory airways
diseases, but whether it leads to changes in the composition of respiratory microbiota is …

[HTML][HTML] Th17 plasticity and its changes associated with inflammatory bowel disease

A Ueno, A Ghosh, D Hung, J Li… - World journal of …, 2015 - ncbi.nlm.nih.gov
CD4 T helper (Th) cell differentiation into distinct T cell subsets is critical to the normal
function of the immune system. Until recently, the paradigm held that naïve T cells …

[HTML][HTML] Effect of rifaximin on gut microbiota composition in advanced liver disease and its complications

FR Ponziani, V Gerardi, S Pecere… - World journal of …, 2015 - ncbi.nlm.nih.gov
Liver cirrhosis is a paradigm of intestinal dysbiosis. The qualitative and quantitative
derangement of intestinal microbial community reported in cirrhotic patients seems to be …

The impact of infection by multidrug‐resistant agents in patients with cirrhosis. A multicenter prospective study

F Salerno, M Borzio, C Pedicino, R Simonetti… - Liver …, 2017 - Wiley Online Library
Abstract Background & Aims Bacterial strains resistant to antibiotics are a serious clinical
challenge. We assessed the antibiotic susceptibility of bacteria isolated from infections in …

The impact of multiplex PCR in diagnosing and managing bacterial infections in COVID-19 patients self-medicated with antibiotics

I Bogdan, C Citu, F Bratosin, D Malita, I Romosan… - Antibiotics, 2022 - mdpi.com
The multiplex PCR is a powerful and efficient tool that was widely used during the COVID-19
pandemic to diagnose SARS-CoV-2 infections and that has applications for bacterial …

Toward culture-free Raman spectroscopic identification of pathogens in ascitic fluid

S Kloß, P Rösch, W Pfister, M Kiehntopf… - Analytical …, 2015 - ACS Publications
The identification of pathogens in ascitic fluid is standardly performed by ascitic fluid culture,
but this standard procedure often needs several days. Additionally, more than half of the …

The prognostic significance of bacterial DNA in patients with decompensated cirrhosis and suspected infection

T Bruns, PA Reuken, S Stengel, L Gerber… - Liver …, 2016 - Wiley Online Library
Abstract Background & Aims Circulating and peritoneal fragments of microbial DNA (bact
DNA) are evidence for bacterial translocation in decompensated cirrhosis and may serve as …

Next-and third-generation sequencing outperforms culture-based methods in the diagnosis of ascitic fluid bacterial infections of ICU patients

H Goelz, S Wetzel, N Mehrbarzin, S Utzolino, G Häcker… - Cells, 2021 - mdpi.com
Objectives: Infections of the ascitic fluid are serious conditions that require rapid diagnosis
and treatment. Ascites is often accompanied by other critical pathologies such as …