[HTML][HTML] DNA topoisomerase I and DNA gyrase as targets for TB therapy
Highlights•DNA topoisomerases are key targets for antibacterial and anticancer
chemotherapy.•TB topo I is validated as an antibacterial target.•Inhibitors that target TB topo I …
chemotherapy.•TB topo I is validated as an antibacterial target.•Inhibitors that target TB topo I …
Indole derivatives as anti-tubercular agents: An overview on their synthesis and biological activities
Background: The indole framework is considered as one of the privileged structures in the
area of medicinal chemistry and drug discovery because compounds containing this …
area of medicinal chemistry and drug discovery because compounds containing this …
Design, synthesis and 2D QSAR study of novel pyridine and quinolone hydrazone derivatives as potential antimicrobial and antitubercular agents
The increased development of highly resistant bacterial strains and tuberculosis, constitute a
serious public health threat, highlighting the urgent need of novel antibacterial agents. In this …
serious public health threat, highlighting the urgent need of novel antibacterial agents. In this …
Mycobacterium Tuberculosis (MTB) GyrB inhibitors: An attractive approach for developing novel drugs against TB
New classes of drugs are needed to treat tuberculosis (TB) in order to combat the
emergence of resistance (MDR and XDR) to existing agents and shorten the duration of …
emergence of resistance (MDR and XDR) to existing agents and shorten the duration of …
Recent progress in the discovery and development of DNA gyrase B inhibitors
New antibacterials that modulate less explored targets are needed to fight the emerging
bacterial resistance. DNA gyrase and topoisomerase IV are attractive targets in this search …
bacterial resistance. DNA gyrase and topoisomerase IV are attractive targets in this search …
Targeting DNA replication and repair for the development of novel therapeutics against tuberculosis
Mycobacterium tuberculosis is the etiological agent of tuberculosis (TB), an infectious
disease which results in approximately 10 million incident cases and 1.4 million deaths …
disease which results in approximately 10 million incident cases and 1.4 million deaths …
Ligand-Based Virtual Screening for Discovery of Indole Derivatives as Potent DNA Gyrase ATPase Inhibitors Active against Mycobacterium tuberculosis and Hit …
B Pakamwong, P Thongdee, B Kamsri… - Journal of Chemical …, 2024 - ACS Publications
Mycobacterium tuberculosis is the single most important global infectious disease killer and
a World Health Organization critical priority pathogen for development of new antimicrobials …
a World Health Organization critical priority pathogen for development of new antimicrobials …
How Mycobacterium tuberculosis drug resistance has shaped anti-tubercular drug discovery
Drug resistance is an increasing problem for the treatment of tuberculosis. The prevalence of
clinical isolates with pre-existing resistance needs to be considered in any drug discovery …
clinical isolates with pre-existing resistance needs to be considered in any drug discovery …
Chemical classes targeting energy supplying GyrB domain of Mycobacterium tuberculosis
Tuberculosis (TB) is contagious in nature and immunocompromised patients have a higher
probability of developing TB. The occurrence of drug resistance, has led to serious health …
probability of developing TB. The occurrence of drug resistance, has led to serious health …
Development of acridine derivatives as selective Mycobacterium tuberculosis DNA gyrase inhibitors
In this study we have designed p-phenylene diamine linked acridine derivative from our
earlier reported quinoline–aminopiperidine hybrid MTB DNA gyrase inhibitors with aiming …
earlier reported quinoline–aminopiperidine hybrid MTB DNA gyrase inhibitors with aiming …