Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …
structures or functions that are difficult to interfere with using conventional drug design …
Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment
The nonreceptor protein tyrosine phosphatase SHP2 (encoded by PTPN11) integrates
growth and differentiation signals from receptor tyrosine kinases (RTKs) into the …
growth and differentiation signals from receptor tyrosine kinases (RTKs) into the …
Recent advance on PTP1B inhibitors and their biomedical applications
B Sharma, L Xie, F Yang, W Wang, Q Zhou… - European Journal of …, 2020 - Elsevier
Abstract Protein Tyrosine Phosphatase 1B (PTP1B), as one of the most important members
in PTP superfamily, plays a vital role in conducting various cellular functions. So far, PTP1B …
in PTP superfamily, plays a vital role in conducting various cellular functions. So far, PTP1B …
A molecular docking and molecular dynamics simulation study on the interaction between cyanidin‐3‐O‐glucoside and major proteins in cow's milk
F Pan, J Li, L Zhao, T Tuersuntuoheti… - Journal of Food …, 2021 - Wiley Online Library
The objective of this study was to investigate the molecular interaction and complex stability
of four major cow's milk (CM) proteins (α‐LA, β‐LG, αs1‐CA, and β‐CA) with cyanidin‐3‐O …
of four major cow's milk (CM) proteins (α‐LA, β‐LG, αs1‐CA, and β‐CA) with cyanidin‐3‐O …
Protective effect and mechanism of action of xanthan gum on the color stability of black rice anthocyanins in model beverage systems
L Zhao, F Pan, A Mehmood, Y Zhang, S Hao… - International Journal of …, 2020 - Elsevier
We investigated the effect and mechanism of action of xanthan gum (XG) on the color
stability of black rice anthocyanins (BRA) in model beverage systems (pH 3.0) containing l …
stability of black rice anthocyanins (BRA) in model beverage systems (pH 3.0) containing l …
Synthesis, molecular docking and enzyme inhibitory approaches of some new chalcones engrafted pyrazole as potential antialzheimer, antidiabetic and antioxidant …
MS Islam, AM Al-Majid, EN Sholkamy, S Yousuf… - Journal of Molecular …, 2022 - Elsevier
About 25 chalcones engrafted pyrazole scaffold combined with benzothiophene and indole
moieties 5a-y were designed and constructed in two steps using readily available acetyl …
moieties 5a-y were designed and constructed in two steps using readily available acetyl …
Site-directed mutagenesis of family GH10 Aspergillus fumigatus xylanase A and the interaction with Oryza sativa xylanase inhibitor protein
H He, J Liu, Y Wang, Y Chen, K Lu, M Liu - Biocatalysis and Agricultural …, 2023 - Elsevier
In this study three alanine mutants (V99A, D145A and V99A/D145A) of family GH10
Aspergillus fumigatus xylanase A (AfXylA10) were engineered and characterized. These …
Aspergillus fumigatus xylanase A (AfXylA10) were engineered and characterized. These …
Molecular Insights into the Role of Pathogenic nsSNPs in GRIN2B Gene Provoking Neurodevelopmental Disorders
The GluN2B subunit of N-methyl-D-aspartate receptors plays an important role in the
physiology of different neurodevelopmental diseases. Genetic variations in the GluN2B …
physiology of different neurodevelopmental diseases. Genetic variations in the GluN2B …
Mechanism of zinc ejection by disulfiram in nonstructural protein 5A
Hepatitis C virus (HCV) is a notorious member of the Flaviviridae family of enveloped,
positive-strand RNA viruses. Non-structural protein 5A (NS5A) plays a key role in HCV …
positive-strand RNA viruses. Non-structural protein 5A (NS5A) plays a key role in HCV …
Proteome-wide mapping and reverse vaccinology-based B and T cell multi-epitope subunit vaccine designing for immune response reinforcement against …
Porphyromonas gingivalis, a prominent pathogen responsible for acute periodontal
diseases, is widely studied by the scientific community for its successful evasion of the host …
diseases, is widely studied by the scientific community for its successful evasion of the host …