The characteristic molecular composition of the different glycosaminoglycans (GAGs) is
related to their role as structural components and regulators of a multitude of functions of …

Blood urea nitrogen (BUN) and serum creatinine (SCr) are not very sensitive and specific
markers of kidney function in acute kidney injury (AKI) as they are influenced by many renal …

Background Intravenous fluids, an essential component of sepsis resuscitation, may
paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models …

Rationale: Degradation of the endothelial glycocalyx, a glycosaminoglycan (GAG)-rich layer
lining the vascular lumen, is associated with the onset of kidney injury in animal models of …

Influenza infection is substantially worsened by the onset of secondary pneumonia caused
by bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). The bidirectional …

The microcirculation, comprised of less than 100 μm–diameter arterioles, capillary beds, and
draining venules, performs essential homeostatic functions, including oxygen delivery and …

Infection stones are complex aggregates of crystals amalgamated in an organic matrix that
are strictly associated with urinary tract infections. The management of patients who form …

Mucopolysaccharidoses (MPS) are inborn errors of metabolism produced by a deficiency of
one of the enzymes involved in the degradation of glycosaminoglycans (GAGs). Although …

This review covers recent developments in glycosaminoglycan (GAG) analysis via mass
spectrometry (MS). GAGs participate in a variety of biological functions, including cellular …

There are no effective targeted therapies to treat acute respiratory distress syndrome
(ARDS). Recently, the commonly used diabetes and obesity medications, glucagon-like …