Mechanisms and pathology of protein misfolding and aggregation
Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …
from fully understanding how proteins fold into their native conformation. The conventional …
Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
[HTML][HTML] ATR-FTIR: A “rejuvenated” tool to investigate amyloid proteins
R Sarroukh, E Goormaghtigh, JM Ruysschaert… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Amyloid refers to insoluble protein aggregates that are responsible for amyloid diseases but
are also implicated in important physiological functions (functional amyloids). The …
are also implicated in important physiological functions (functional amyloids). The …
Molecular basis for amyloid-β polymorphism
JP Colletier, A Laganowsky… - Proceedings of the …, 2011 - National Acad Sciences
Amyloid-beta (Aβ) aggregates are the main constituent of senile plaques, the histological
hallmark of Alzheimer's disease. Aβ molecules form β-sheet containing structures that …
hallmark of Alzheimer's disease. Aβ molecules form β-sheet containing structures that …
ANS binding reveals common features of cytotoxic amyloid species
Oligomeric assemblies formed from a variety of disease-associated peptides and proteins
have been strongly associated with toxicity in many neurodegenerative conditions, such as …
have been strongly associated with toxicity in many neurodegenerative conditions, such as …
Cerebrospinal fluid: A specific biofluid for the biosensing of Alzheimer's diseases biomarkers
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder with an
irreversible, progressive, and untreatable nature that causes progressive deterioration, loss …
irreversible, progressive, and untreatable nature that causes progressive deterioration, loss …
Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases
The intricate process of α-synuclein aggregation and fibrillization holds pivotal roles in
Parkinson's disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can …
Parkinson's disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can …
Modulation of Alzheimer's Disease Aβ40 Fibril Polymorphism by the small heat shock protein αB-Crystallin
Deposition of amyloid plaques in the brains of Alzheimer's disease (AD) patients is a
hallmark of the disease. AD plaques consist primarily of the beta-amyloid (Aβ) peptide but …
hallmark of the disease. AD plaques consist primarily of the beta-amyloid (Aβ) peptide but …
Protein aggregation: mechanisms and functional consequences
Understanding the mechanisms underlying protein misfolding and aggregation has become
a central issue in biology and medicine. Compelling evidence show that the formation of …
a central issue in biology and medicine. Compelling evidence show that the formation of …