Abstract Development of peripheral nervous system (PNS) myelin involves a coordinated
series of events between growing axons and the Schwann cell (SC) progenitors that will …

Abstract Charcot–Marie–Tooth disease (CMT) is the most frequent form of inherited
neuropathy with great variety of phenotypes, inheritance patterns, and causative genes …

The X-linked form of Charcot–Marie–Tooth disease (CMT1X) is the second most common
form of hereditary motor and sensory neuropathy. The clinical phenotype is characterized by …

CNS glia and neurons express connexins, the proteins that form gap junctions in
vertebrates. We review the connexins expressed by oligodendrocytes and astrocytes, and …

The gap junction (GJ) protein connexin32 (Cx32) is expressed by myelinating Schwann
cells and oligodendrocytes and is mutated in X-linked Charcot-Marie-Tooth disease. In …

In addition to the extensive gap junction coupling between astrocytes themselves,
oligodendrocytes are thought to be exclusively coupled to astrocytes (O: A coupling) via …

Under physiological conditions, microglia adopt a resting phenotype associated with the
production of anti-inflammatory and neurotrophic factors. In response to a wide variety of …

X-linked Charcot-Marie-Tooth disease (CMTX) is the second common genetic variant of
CMT. CMTX type 1 causes 90% of CMTX. The most important clinical features of CMTX are …

X-linked Charcot-Marie-Tooth disease type 1 (CMT1X) is a demyelinating neuropathy
resulting from loss-of-function mutations affecting the GJB1/connexin 32 (Cx32) gene. We …

Connexin 32 (Cx32) is a fundamental protein in the peripheral nervous system (PNS) as its
mutations cause the X-linked form of Charcot–Marie–Tooth disease (CMT1X), the second …