The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …

Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous
compounds, including lipid esters. Physiological functions of carboxylesterases in lipid …

Exposure to ubiquitous plastic-associated endocrine disrupting chemicals (EDCs) is
associated with the increased risk of many chronic diseases. For example, phthalate …

Although mitochondrial disorders are clinically heterogeneous, they frequently involve the
central nervous system and are among the most common neurogenetic disorders …

Carboxylesterases (CEs) are a class of enzymes that catalyze the hydrolysis of esters in a
variety of endogenous and exogenous molecules. CEs play an important role in drug …

Non-alcoholic steatohepatitis (NASH) represents a global health concern. It is characterised
by fatty liver, hepatocyte cell death and inflammation, which are associated with lipotoxicity …

Background The development of a safe, effective, reversible, non-hormonal contraceptive
method for men has been an ongoing effort for the past few decades. However, despite …

The liver plays a unique, central role in regulating lipid metabolism. In addition to influencing
hepatic function and disease, changes in specific pathways of fatty acid (FA) metabolism …

Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin
resistance and a systemic pro-inflammatory response. Here we show that tumour necrosis …

Serine hydrolases are a large family of multifunctional enzymes known to influence obesity.
Here, we performed activity-based protein profiling to assess the functional level of serine …