Differential gene expression mechanisms ensure cellular differentiation and plasticity to
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …

A class of cis-regulatory elements, called enhancers, play a central role in orchestrating
spatiotemporally precise gene-expression programs during development. Consequently …

INTRODUCTION The ability to regenerate tissues lost to damage or disease is widely but
nonuniformly distributed in vertebrates. Some animals such as teleost fishes can regenerate …

Evolvability is the ability of a biological system to produce phenotypic variation that is both
heritable and adaptive. It has long been the subject of anecdotal observations and …

Cis-regulatory sequences, such as enhancers and promoters, control development and
physiology by regulating gene expression. Mutations that affect the function of these …

There is abundant variation in gene expression between individuals, populations, and
species. The evolution of gene regulation and expression within and between species is …

What is the nature of the genetic changes underlying phenotypic evolution? We have
catalogued 1008 alleles described in the literature that cause phenotypic differences among …

The hypothesis that differences in gene regulation have an important role in speciation and
adaptation is more than 40 years old. With the advent of new sequencing technologies, we …

The study of molecular evolution at the level of protein-coding genes often entails comparing
large datasets of sequences to infer their evolutionary relationships. Despite the importance …

Genomes of eusocial insects code for dramatic examples of phenotypic plasticity and social
organization. We compared the genomes of seven ants, the honeybee, and various solitary …