Advances and Challenges in the Development of Immobilized Enzymes for Batch and Flow Biocatalyzed Processes

S Patti, I Magrini Alunno, S Pedroni, S Riva… - …, 2024 - Wiley Online Library
The development of immobilized enzymes both for batch and continuous flow biocatalytic
processes has gained significant traction in recent years, driven by the need for cost …

[HTML][HTML] Dynamic Flow Experiments for Data-Rich Optimization

JD Williams, P Sagmeister, CO Kappe - Current Opinion in Green and …, 2024 - Elsevier
Flow chemistry is having an increasing influence on manufacturing in the chemical industry,
but significant barriers remain in the development of these continuous processes. Dynamic …

Three-Step Continuous Flow Synthesis of the Intermediate 4-Fluoro-2-methoxy-5-nitrophenol of Linzagolix

T Gong, F Ji, Y Shi, Y Dong, Y Xia, F Wu… - … Process Research & …, 2024 - ACS Publications
4-Fluoro-2-methoxy-5-nitrophenol is a key intermediate of the GnRH receptor antagonist
Linzagolix. The traditional synthetic methods have several disadvantages including …

Two‐Step Biocatalytic Synthesis of (1S)‐Nor(pseudo)ephedrine Catalyzed by Immobilized Enzymes

S Patti, I Magrini Alunno, R Semproli… - …, 2024 - Wiley Online Library
Abstract Nor (pseudo) ephedrines [N (P) Es] are naturally occurring compounds showing
sympathomimetic activity that have many applications especially in the chemical industry …