The transcription factor family activator protein 2 (TFAP2) is vital for regulating both
embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding …

Abstract The Activator Protein 2 (AP-2) transcription factor (TF) family is vital for the
regulation of gene expression during early development as well as carcinogenesis process …

The TFAP2 family regulates gene expression during differentiation, development, and
organogenesis, and includes five homologs in humans. They all possess a highly conserved …

Trastuzumab resistance in HER2+ breast cancer (BC) is the major reason leading to poor
prognosis of BC patients. Oncogenic gene overexpression or aberrant activation of tyrosine …

Cellular reprogramming converts differentiated cells into induced pluripotent stem cells
(iPSCs). However, this process is typically very inefficient, complicating mechanistic studies …

Transcription factors are known to mediate the conversion of somatic cells to induced
pluripotent stem cells (iPSCs). Transcription factor TFAP2C plays important roles in the …

The epithelial-mesenchymal transition (EMT) regulator, Slug, plays multifaceted roles in
controlling lung cancer progression, but its downstream targets and mechanisms in …

Expression of TFAP2C in luminal breast cancer is associated with reduced survival and
hormone resistance, partially explained through regulation of RET. TFAP2C also regulates …

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype
characterised by extensive intratumoral heterogeneity, high rates of metastasis and …

Abstract Activator Protein 2 gamma (AP-2γ) is a master transcription factor that plays a
critical role in the development and progression of breast cancer. However, the underlying …