Brain delivery is one of the major challenges in drug development because of the high
number of patients suffering from neural diseases and the low efficiency of the treatments …

The blood–brain barrier (BBB) is a highly regulated and efficient barrier that provides a
sanctuary to the brain. It is designed to regulate brain homeostasis and to permit selective …

Background and Purpose—Traditionally, cell death after cerebral ischemia was considered
to be exclusively necrotic in nature, but research over the past decade has revealed that …

Adsorptive-mediated transcytosis (AMT) provides a means for brain delivery of medicines
across the blood-brain barrier (BBB). The BBB is readily equipped for the AMT process: it …

Traumatic brain injury (TBI) is a major health and socioeconomic problem throughout the
world. It is a complicated pathological process that consists of primary insults and a …

ABSTRACT Introduction: Cell penetrating peptides (CPPs) known as protein translocation
domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able …

Although the prevailing concept has been that mortality in sepsis results from an unbridled
hyper-inflammatory cytokine-mediated response, the failure of more than 30 clinical trials to …

Acute neurological conditions such as cerebrovascular diseases and trauma are associated
with irreversible loss of neurons and glial cells. Severe or prolonged injury results in …

Therapeutic peptides are attracting increasing attention for biomedical applications.
Peptides present promising opportunities in targeted drug delivery due to their high …

There is currently no approved neuroprotective pharmacotherapy for acute conditions such
as stroke and cerebral asphyxia. One of the reasons for this may be the multiplicity of cell …