The effects of serotonin in immune cells

N Herr, C Bode, D Duerschmied - Frontiers in cardiovascular …, 2017 - frontiersin.org
Serotonin [5-hydroxytryptamine (5-HT)] plays an important role in many organs as a
peripheral hormone. Most of the body's serotonin is circulating in the bloodstream …

Psychedelics as anti-inflammatory agents

TW Flanagan, CD Nichols - International Review of Psychiatry, 2018 - Taylor & Francis
Abstract Serotonin (5-hydroxytryptamine, 5-HT) 2A receptor agonists have recently emerged
as promising new treatment options for a variety of disorders. The recent success of these …

Role of serotonin in the immune system and in neuroimmune interactions

R Mössner, KP Lesch - Brain, behavior, and immunity, 1998 - Elsevier
Serotonin (5-HT) is one of the most extensively studied neurotransmitters of the central
nervous system. 5-HT is, however, also present in a variety of peripheral tissues including in …

Effects of antidepressants on the production of cytokines

G Kenis, M Maes - International Journal of …, 2002 - academic.oup.com
There is now evidence that major depression is associated with an up-regulation of the
inflammatory response system (IRS). One of the major factors in this IRS activation is the …

Serotonin skews human macrophage polarization through HTR2B and HTR7

M de las Casas-Engel, A Domínguez-Soto… - The Journal of …, 2013 - journals.aai.org
Besides its role as a neurotransmitter, serotonin (5-hydroxytryptamine, 5HT) regulates
inflammation and tissue repair via a set of receptors (5HT 1–7) whose pattern of expression …

Drug repurposing of selective serotonin reuptake inhibitors: Could these drugs help fight COVID-19 and save lives?

Y Pashaei - Journal of Clinical Neuroscience, 2021 - Elsevier
The current 2019 novel coronavirus disease (COVID-19), an emerging infectious disease, is
undoubtedly the most challenging pandemic in the 21st century. A total of 92,977,768 …

Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice

T Yamaguchi, T Nagasawa, M Satoh, Y Kuraishi - Neuroscience research, 1999 - Elsevier
Serotonin (5-HT) is pruritogenic in humans and suggested to be involved in some pruritic
diseases. Our experiments were carried out to determine whether an intradermal injection of …

Effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor α and interleukin-6

M Kubera, M Maes, G Kenis, YK Kim, W Lasoń - Psychiatry research, 2005 - Elsevier
Serotonin (5-HT) is a neurotransmitter and immune modulator. The effect of 5-HT on the
production of cytokines by human macrophages and lymphocytes is poorly recognized. In …

Differential effect of serotonin on cytokine production in lipopolysaccharide‐stimulated human peripheral blood mononuclear cells: involvement of 5 …

I Cloëz‐Tayarani, AF Petit‐Bertron… - International …, 2003 - academic.oup.com
In order to provide additional insight into the in vivo significance of serotonin [5‐
hydroxytryptamine (5‐HT)] in inflammation, we examined its effect on the production of tumor …

The effect of antidepressants on the severity of COVID-19 in hospitalized patients: A systematic review and meta-analysis

H Nakhaee, M Zangiabadian, R Bayati, M Rahmanian… - PLoS …, 2022 - journals.plos.org
Introduction Clinical Depression and the subsequent low immunity is a comorbidity that can
act as a risk factor for the severity of COVID-19 cases. Antidepressants such as Selective …