Background Theories of the intergenerational transmission of depression emphasize
alterations in emotion processing among offspring of depressed mothers as a key risk …

Social rewards are strong drivers of behavior and fundamental to well-being, yet there is a
lack of consensus regarding what actually defines a reward as “social.” Because a …

Depression is a highly prevalent and debilitating mental disorder that often begins in
adolescence. However, it remains unclear whether adults and adolescents with depression …

Background Social rewards (eg, social feedback, praise, and social interactions) are
fundamental to social learning and relationships across the life span. Exposure to social …

Pain disorders and psychiatric illness are strongly comorbid, particularly in the context of
Major Depressive Disorder (MDD). While these disorders account for a significant amount of …

Background Although social rejection is among the strongest proximal precipitants of major
depressive disorder (MDD), little is known about the underlying neurobiological …

Structural and functional brain alterations are found in adults with depression. It is not known
whether these changes are a result of illness or exist prior to disorder onset. Asymptomatic …

Background A growing body of research has demonstrated that adolescent offspring of
depressed parents show diminished responding in the ventral striatum to reward. More …

Experiencing stressful events early in life is lamentably very common and widespread
across the globe. Despite the strong link between experiencing such stress and developing …

Background Family history of depression is a robust predictor of early-onset depression,
which may confer risk through alterations in neural circuits that have been implicated in …