Palladium extraction following metal-catalyzed reactions: recent advances and applications in the pharmaceutical industry

M Economidou, N Mistry… - … Process Research & …, 2023 - ACS Publications
Palladium-catalyzed cross-coupling reactions are used extensively in the pharmaceutical
industry. Therefore, the potential contamination of products with elemental impurities is an …

High throughput analysis enables high throughput experimentation in pharmaceutical process research

CJ Welch - Reaction Chemistry & Engineering, 2019 - pubs.rsc.org
High throughput experimentation has become widely used in the discovery and
development of new medicines. Progress in the field relies on an interplay between high …

Pd (5%)-KIT-6, Pd (5%)-SBA-15 and Pd (5%)-SBA-16 catalysts in water extract of pomegranate ash: a case study in heterogenization of Suzuki-Miyaura reaction …

J Lakshmidevi, V Vakati, BR Naidu… - Sustainable Chemistry …, 2021 - Elsevier
Abstract Real heterogenization of Suzuki-Miyaura cross-coupling (SMC) is arduous quest
owing to unavoidable homogeneous mechanism of heterogeneous catalysts. This article …

Catalyst development for the synthesis of ozonides and tetraoxanes under heterogeneous conditions: Disclosure of an unprecedented class of fungicides for …

IA Yaremenko, PS Radulov… - … A European Journal, 2020 - Wiley Online Library
Abstract The catalyst H3+ xPMo12− x+ 6Mox+ 5O40 supported on SiO2 was developed for
peroxidation of 1, 3‐and 1, 5‐diketones with hydrogen peroxide with the formation of …

Effective method to remove metal elements from pharmaceutical intermediates with polychelated resin scavenger

H Miyamoto, C Sakumoto, E Takekoshi… - … Process Research & …, 2015 - ACS Publications
A catalytic reaction is an important methodology for the production of pharmaceuticals from
the viewpoint of green and sustainable chemistry. Since elemental impurity levels should be …

Highly efficient and time economical purification of olefin metathesis products from metal residues using an isocyanide scavenger

G Szczepaniak, A Ruszczyńska, K Kosiński… - Green …, 2018 - pubs.rsc.org
A sustainable protocol of olefin metathesis in non-degassed, undistilled ethyl acetate under
air with commercially available self-scavenging ruthenium catalysts is described …

Potassium isopropyl xanthate (PIX): an ultra-efficient palladium scavenger

H Ren, CA Strulson, G Humphrey, R Xiang, G Li… - Green …, 2017 - pubs.rsc.org
The increasing employment of palladium-catalyzed reactions in the synthesis of active
pharmaceutical ingredients (APIs) has created a pressing need for ultra-efficient palladium …

The destiny of palladium: Development of efficient palladium analysis techniques in enhancing palladium recovery

S Tu, S Yusuf, M Muehlfeld, R Bauman… - … Process Research & …, 2019 - ACS Publications
The palladium-catalyzed cross-coupling reaction is a widely used protocol to build C–C or C–
heteroatom bonds in organic synthesis in both academic research and industrial production …

A ratiometric fluorescent probe for determining Pd 2+ ions based on coordination

B Qiao, S Sun, N Jiang, S Zhang, X Peng - Dalton Transactions, 2014 - pubs.rsc.org
An aniline–rhodamine-based ratiometric fluorescent probe (RI) was designed and
synthesized. RI, the metal coordinating chromophoric ligand, exhibited high selectivity and …

A competitive and reversible deactivation approach to catalysis-based quantitative assays

K Koide, MP Tracey, X Bu, J Jo, MJ Williams… - Nature …, 2016 - nature.com
Catalysis-based signal amplification makes optical assays highly sensitive and widely useful
in chemical and biochemical research. However, assays must be fine-tuned to avoid signal …