Neurogenesis in primates versus rodents and the value of non-human primate models
R Zhang, H Quan, Y Wang, F Luo - National Science Review, 2023 - academic.oup.com
Neurogenesis, the process of generating neurons from neural stem cells, occurs during both
embryonic and adult stages, with each stage possessing distinct characteristics. Dysfunction …
embryonic and adult stages, with each stage possessing distinct characteristics. Dysfunction …
[HTML][HTML] Cortical somatostatin long-range projection neurons and interneurons exhibit divergent developmental trajectories
J Fisher, M Verhagen, Z Long, M Moissidis, Y Yan… - Neuron, 2024 - cell.com
The mammalian cerebral cortex contains an extraordinary diversity of cell types that emerge
by implementing different developmental programs. Delineating when and how cellular …
by implementing different developmental programs. Delineating when and how cellular …
Progress of reprogramming astrocytes into neuron
S Liu, X Xu, E Omari-Siaw, J Yu, W Deng - Molecular and Cellular …, 2024 - Elsevier
As the main players in the central nervous system (CNS), neurons dominate most life
activities. However, after accidental trauma or neurodegenerative diseases, neurons are …
activities. However, after accidental trauma or neurodegenerative diseases, neurons are …
[HTML][HTML] Drug discovery and development in the era of artificial intelligence: From machine learning to large language models
S Guan, G Wang - Artificial Intelligence Chemistry, 2024 - Elsevier
Abstract Drug Research and Development (R&D) is a complex and difficult process, and
current drug R&D faces the challenges of long time span, high investment, and high failure …
current drug R&D faces the challenges of long time span, high investment, and high failure …
Transcriptional Control of Neocortical Size and Microcephaly
The neocortex varies in size and complexity among mammals due to the tremendous
variability in the number and diversity of neuronal subtypes across species. The increased …
variability in the number and diversity of neuronal subtypes across species. The increased …
Tanycyte radial morphology and proliferation are influenced by fibroblast growth factor receptor 1 and high‐fat diet
NA Esteve, DJ Rogers, JA Stagray… - European Journal of …, 2024 - Wiley Online Library
Fibroblast growth factor receptor 1 (FGFR1) is a widely expressed, membrane‐bound
receptor that transduces extracellular signals from FGF ligands and cadherins, resulting in …
receptor that transduces extracellular signals from FGF ligands and cadherins, resulting in …
Brain and Organoid Manifold Alignment (BOMA), a machine learning framework for comparative gene expression analysis across brains and organoids
C He, NC Kalafut, SO Sandoval, R Risgaard, C Yang… - bioRxiv, 2022 - biorxiv.org
Organoids have become valuable models for understanding cellular and molecular
mechanisms in human development including brains. However, whether developmental …
mechanisms in human development including brains. However, whether developmental …