Aging is the most prominent risk factor for late-onset Alzheimer's disease. Aging associates
with a chronic inflammatory state both in the periphery and in the central nervous system, the …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that comprises
amyloid-beta protein (Aβ) as a main component of neuritic plaques. Its deposition is …

The role of metals in the pathogenesis of Alzheimer's disease (AD) is still debated. Although
previous research has linked changes in essential metal homeostasis and exposure to …

Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with
cognitive impairment and dementia, which has become a major public health problem …

Alzheimer's disease's pathophysiology is still a conundrum. Growing number of evidences
have elucidated the involvement of oxidative stress in the pathology of AD rendering it a …

Parkinson's disease is a neurodegenerative disease exhibiting the fastest growth in
incidence in recent years. As with most neurodegenerative diseases, the pathophysiology is …

Synaptic mitochondria are crucial for maintaining synaptic activity due to their high energy
requirements, substantial calcium (Ca 2+) fluctuation, and neurotransmitter release at the …

Progress made by the medical community in increasing lifespans comes with the costs of
increasing the incidence and prevalence of age-related diseases, neurodegenerative ones …

The strong association between gut microbiota (GM) and brain functions such as mood,
behaviour, and cognition has been well documented. Gut-brain axis is a unique bidirectional …

In a search for new antioxidants, a set of new iodoquinazolinone derivatives bearing
benzenesulfonamide moiety and variable acetamide pharmacophores 5–17 were designed …