Ferroptosis is a type of regulated necrosis caused by unrestricted lipid peroxidation and
subsequent plasma membrane rupture. However, the lipid remodeling mechanism that …

Sepsis is described as a life-threatening organ dysfunction and a heterogeneous syndrome
that is a leading cause of morbidity and mortality in intensive care settings. Severe sepsis …

Lipopolysaccharide (LPS), a key component of the outer membrane in Gram-negative
bacteria (GNB), is widely recognized for its crucial role in mammalian innate immunity and …

The Krebs cycle-derived metabolite itaconate, whose production is catalyzed by immune
response gene 1 (IRG1), has potential to link immunity and metabolism in activated …

Itaconate is an immunomodulatory metabolite produced by immune cells under microbial
stimulation and certain pro-inflammatory conditions and triggers antioxidant and anti …

Ferroptosis is a type of regulated cell death characterized by lipid peroxidation and
subsequent damage to the plasma membrane. Here, we report a ferroptosis resistance …

Despite recent advances, severe acute pancreatitis (SAP) remains a lethal inflammation with
limited treatment options. Here, we provide compelling evidence of GV-971 (sodium …

The liver is the main site of colorectal cancer (CRC) metastasis. Tumor-associated
macrophages (TAMs) play a key role in tumor metastasis. Therefore, modulating the function …

Abstract cis-Aconitate decarboxylase (ACOD1, IRG1) converts cis-aconitate to the
immunomodulatory and antibacterial metabolite itaconate. Although the active site residues …

Immune cells are metabolically plastic and respond to inflammatory stimuli with large shifts
in metabolism. Itaconate is one of the most up-regulated metabolites in macrophages in …