Adrenergic receptors (AR) are G-protein-coupled receptors (GPCRs) that have a crucial role
in cardiac physiology in health and disease. Alpha 1-ARs signal through Gα q, and signaling …

Despite a high prevalence of sudden cardiac death throughout the world, the mechanisms
that lead to ventricular arrhythmias are not fully understood. Over the last 20 years, a …

Duration of heart rate corrected QT interval (QTc) is a crucial and critical factor in the
assessment of repolarization changes considering safety of drugs and cardiac disorders. In …

Evidence from cell, animal, and human studies demonstrates that α1-adrenergic receptors
mediate adaptive and protective effects in the heart. These effects may be particularly …

Ventricular arrhythmias, mainly lethal arrhythmias, such as ventricular tachycardia and
fibrillation, may lead to sudden cardiac death. These are triggered as a result of cardiac …

AIMS: This study aims to investigate the role of peripheral δ2 opioid receptors in cardiac
tolerance to ischemia/reperfusion injury and to examine the contribution of PKC, TK, KATP …

Mitochondria have long been recognized for their central role in energy transduction and
apoptosis. More recently, extensive work in multiple laboratories around the world has …

Abstract Background/Aims: Arctigenin (ATG) has been shown to possess anti-inflammatory,
immunemodulatory, anti-viral, anti-microbial, anti-carcinogenic, vasodilatory and anti …

Oxytocin (OT) is well known for its role in reproduction. However, evidence has emerged
suggesting a role in cardiovascular system. The aim of this study was to investigate the …

Wenxin Keli is the first state‑sanctioned traditional Chinese medicine (TCM)-based
antiarrhythmic drug. The present study aimed to examine whether long‑term treatment with …