[HTML][HTML] [64Cu] XYIMSR-06: A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma
Carbonic anhydrase IX (CAIX) is a cell surface enzyme that is over-expressed in
approximately 95% of cases of clear cell renal cell carcinoma (ccRCC), the most common …
approximately 95% of cases of clear cell renal cell carcinoma (ccRCC), the most common …
[HTML][HTML] Imaging of carbonic anhydrase IX with an 111In-labeled dual-motif inhibitor
We developed a new scaffold for radionuclide-based imaging and therapy of clear cell renal
cell carcinoma (ccRCC) targeting carbonic anhydrase IX (CAIX). Compound XYIMSR-01, a …
cell carcinoma (ccRCC) targeting carbonic anhydrase IX (CAIX). Compound XYIMSR-01, a …
Structural and biochemical characterization of the folyl‐poly‐γ‐l‐glutamate hydrolyzing activity of human glutamate carboxypeptidase II
M Navrátil, J Ptáček, P Šácha, J Starková… - The FEBS …, 2014 - Wiley Online Library
In addition to its well‐characterized role in the central nervous system, human glutamate
carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small …
carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small …
[HTML][HTML] GCPII and its close homolog GCPIII: from a neuropeptidase to a cancer marker and beyond
B Vorlova, T Knedlik, J Tykvart… - Frontiers in Bioscience …, 2019 - imrpress.com
Glutamate carboxypeptidases II and III (GCPII and GCPIII) are highly homologous di-zinc
metallopeptidases belonging to the M28 family. These enzymes are expressed in a variety …
metallopeptidases belonging to the M28 family. These enzymes are expressed in a variety …
Carborane-containing urea-based inhibitors of glutamate carboxypeptidase II: Synthesis and structural characterization
Glutamate carboxypeptidase II (GCPII) is a zinc metalloprotease on the surface of astrocytes
which cleaves N-acetylaspartylglutamate to release N-acetylaspartate and glutamate. GCPII …
which cleaves N-acetylaspartylglutamate to release N-acetylaspartate and glutamate. GCPII …
A Structure‐Activity Relationship Study of Bimodal BODIPY‐Labeled PSMA‐Targeting Bioconjugates
T Stemler, C Hoffmann, IM Hierlmeier, S Maus… - …, 2021 - Wiley Online Library
The aim of this study was to identify a high‐affinity BODIPY peptidomimetic that targets the
prostate‐specific membrane antigen (PSMA) as a potential bimodal imaging probe for …
prostate‐specific membrane antigen (PSMA) as a potential bimodal imaging probe for …
Identify liver X receptor β modulator building blocks by developing a fluorescence polarization-based competition assay
Z Zhang, H Chen, Z Chen, P Ding, Y Ju, Q Gu… - European Journal of …, 2019 - Elsevier
The liver X receptors (LXRs) of the nuclear receptor family are promising therapeutic targets
of multiple diseases like lipid disorders, chronic inflammation, as well as different human …
of multiple diseases like lipid disorders, chronic inflammation, as well as different human …
The calcium‐binding site of human glutamate carboxypeptidase II is critical for dimerization, thermal stability, and enzymatic activity
J Ptacek, J Nedvedova, M Navratil, B Havlinova… - Protein …, 2018 - Wiley Online Library
Calcium ions are required for proper function of a wide spectrum of proteins within cells. X‐
ray crystallography of human glutamate carboxypeptidase II (GCPII) revealed the presence …
ray crystallography of human glutamate carboxypeptidase II (GCPII) revealed the presence …
高通量药物筛选模型的研究进展
许媛媛， 陈鹏辉， 吴英理 - 上海交通大学学报(医学版), 2013 - xuebao.shsmu.edu.cn
高通量药物筛选模型的研究进展 上海交通大学学报(医学版) 首页 期刊介绍 编委会 常见问题 政策
指南 投稿指南 伦理政策 评审与编辑 版权与存储 GenAI相关政策 开放获取政策 联系我们 English …
指南 投稿指南 伦理政策 评审与编辑 版权与存储 GenAI相关政策 开放获取政策 联系我们 English …
Multifunktionelle Radioliganden für das Prostataspezifische Membranantigen
T Stemler - 2023 - publikationen.sulb.uni-saarland.de
Das Prostatakarzinom (PCa) zählt zu einer der häufigsten Tumorentitäten bei Männern
weltweit. Ein innovativer Ansatz der Nuklearmedizin nutzt für die Diagnostik und die …
weltweit. Ein innovativer Ansatz der Nuklearmedizin nutzt für die Diagnostik und die …