There has been extensive progress in understanding the cellular and molecular
mechanisms of inflammation and immune regulation in allergic diseases of the skin and …

In addition to susceptibility to infections, conventional primary immunodeficiency disorders
(PIDs) and inborn errors of immunity (IEI) can cause immune dysregulation, manifesting as …

We report the updated classification of Inborn Errors of Immunity/Primary
Immunodeficiencies, compiled by the International Union of Immunological Societies Expert …

Background & aims Monogenic forms of inflammatory bowel disease (IBD) illustrate the
essential roles of individual genes in pathways and networks safeguarding immune …

Evans syndrome (ES) is a rare severe autoimmune disorder characterized by the
combination of autoimmune hemolytic anemia and immune thrombocytopenia. In most …

Infections with any of the nine human herpes viruses (HHV) can be asymptomatic or life-
threatening. The study of patients with severe diseases caused by HHVs, in the absence of …

Giant condyloma acuminatum, also known as Buschke-Lowenstein tumor (BLT), is a rare
disease of the anogenital region. BLT is considered a locally aggressive tumor of benign …

Key research advances in atopic dermatitis (AD) suggest the complexity of its endotypes. A
comprehensive serum biomarker panel revealed at least 4 types of AD. Some represent …

Clinically and pathologically, the patients with hyper-IgE syndrome present similar skin
manifestations to common atopic dermatitis. The original hyper-IgE syndrome is …

Inborn errors of immunity (IEI) are a heterogenous group of disorders driven by genetic
defects that functionally impact the development and/or function of the innate and/or …