Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Both absent in melanoma 2 (AIM2) and interferon-inducible protein 16 (IFI16) are
intracellular innate immune receptors that recognize double-stranded DNA released during …

DNA virus infections are often lifelong and can cause serious diseases in their hosts. Their
recognition by the sensors of the innate immune system represents the front line of host …

Summary PYHIN proteins AIM2 and IFI204 sense pathogen DNA, while other PYHINs have
been shown to regulate host gene expression through as-yet unclear mechanisms. We …

The innate immune system defenses against pathogen infections via patten-recognition
receptors (PRRs). PRRs initiate immune responses by recognizing pathogen-associated …

Abstract IFI16 (Interferon inducible protein 16) is a DNA sensor responsible for innate
immune response stimulation and a direct viral restriction by modulating gene expression …

The hematopoietic interferon-inducible nuclear (HIN) domain of the PYHIN family of proteins
recognizes double-stranded DNA (dsDNA) through different dsDNA-binding modes. These …

Cytosolic DNA sensors are a group of pattern recognition receptors (PRRs) that vary in
structures, molecular mechanisms, and origins but share a common function to detect …

The tertiary and quaternary structures of many proteins are stabilized by strong covalent
forces, of which disulfide bonds are the most well known. A new type of intramolecular and …

The mechanism by which DNA viruses interact with different DNA sensors and their
connection with the activation of interferon (IFN) type I pathway are poorly understood. We …