Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …

Cell death is a fundamental pathophysiological process in human disease. The discovery of
necroptosis, a form of regulated necrosis that is induced by the activation of death receptors …

Cancers arise through the accumulation of genetic and epigenetic alterations that enable
cells to evade telomere-based proliferative barriers and achieve immortality. One such …

Nucleic acid sensing is a central process in the immune system, with far-reaching roles in
antiviral defense, autoinflammation, and cancer. Z-DNA binding protein 1 (ZBP1) is a sensor …

Innate immunity is not only the first line of host defense against microbial infections but is
also crucial for the host responses against a variety of noxious stimuli. Z-DNA binding …

Aging is marked by the gradual accumulation of deleterious changes that disrupt organ
function, creating an altered physiological state that is permissive for the onset of prevalent …

Multiple myeloma is a genetically heterogeneous cancer of the bone marrow plasma cells
(PC). Distinct myeloma transcriptome profiles are primarily driven by myeloma initiating …

Understanding the biological and clinical impact of copy number aberrations (CNAs) on the
development of precision therapies in cancer remains an unmet challenge. Genetic …

Alzheimer's disease (AD) is one of the leading causes of death throughout the world. Z-DNA
binding protein 1 (ZBP1), a DNA-related gene, is associated with inflammation, and its …

Abstract Z-DNA binding protein 1 (ZBP1), a cytosolic nucleic acid sensor for Z-form nucleic
acids (Z-NA), can detect both exogenous and endogenous nucleic acids. Upon sensing of …