Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications

Y Wu, K Chen, J Wang, M Chen, Y Chen, Y She… - Progress in Polymer …, 2023 - Elsevier
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …

Antimicrobial peptides: A potent alternative to antibiotics

M Rima, M Rima, Z Fajloun, JM Sabatier, B Bechinger… - Antibiotics, 2021 - mdpi.com
Antimicrobial peptides constitute one of the most promising alternatives to antibiotics since
they could be used to treat bacterial infections, especially those caused by multidrug …

Short guanidinium‐functionalized poly (2‐oxazoline) s displaying potent therapeutic efficacy on drug‐resistant fungal infections

W Jiang, M Zhou, Z Cong, J Xie, W Zhang… - Angewandte …, 2022 - Wiley Online Library
New antifungals are urgently needed to combat invasive fungal infections, due to limited
types of available antifungal drugs and frequently encountered side effects, as well as the …

The future of poly (2-oxazoline) s

R Hoogenboom - European Polymer Journal, 2022 - Elsevier
Abstract Poly (2-oxazoline) s have gained significant interest in the past decade, especially
driven by their high potential for biomedical applications, amongst others to substitute poly …

Peptide Polymer‐Doped Cement Acting as an Effective Treatment of MRSA‐Infected Chronic Osteomyelitis

Y Wu, Y Lin, Z Cong, K Chen, X Xiao… - Advanced Functional …, 2022 - Wiley Online Library
Chronic osteomyelitis is a painful and serious disease normally caused by infected surgical
prostheses or infected fractures. Currently, antibiotic‐loaded cements are extensively used …

Discovery of Amphiphilic Xanthohumol Derivatives as Membrane-Targeting Antimicrobials against Methicillin-Resistant Staphylococcus aureus

W Cheng, T Xu, L Cui, Z Xue, J Liu… - Journal of Medicinal …, 2022 - ACS Publications
Infections caused by multidrug-resistant (MDR) bacteria are increasing worldwide, and with
limited clinically available antibiotics, it is urgent to develop new antimicrobials to combat …

Switching from membrane disrupting to membrane crossing, an effective strategy in designing antibacterial polypeptide

H Zhang, Q Chen, J Xie, Z Cong, C Cao, W Zhang… - Science …, 2023 - science.org
Drug-resistant bacterial infections have caused serious threats to human health and call for
effective antibacterial agents that have low propensity to induce antimicrobial resistance …

Host-defense-peptide-mimicking β-peptide polymer acting as a dual-modal antibacterial agent by interfering quorum sensing and killing individual bacteria …

W Li, X Xiao, Y Qi, X Lin, H Hu, M Shi, M Zhou, W Jiang… - Research, 2023 - spj.science.org
Host defense peptides (HDPs) are one of the potentially promising agents for infection
diseases due to their broad spectrum and low resistance rate, but their clinical applications …

Engineering Phenothiazine-Based Functional Mimics of Host Defense Peptides as New Agrochemical Candidates: Design, Synthesis, and Antibacterial Evaluation

WB Shao, RS Luo, J Meng, XK Lv… - Journal of Agricultural …, 2023 - ACS Publications
In the protracted “arms race” between host and plant pathogenic bacteria, host organisms
have evolved powerful weapons known as host defense peptides (HDPs). However, natural …

Peptide-mimicking poly (2-oxazoline) displaying potent antibacterial and antibiofilm activities against multidrug-resistant Gram-positive pathogenic bacteria

Z Cong, Z Yan, X Xiao, L Liu, Z Luo, J Zou… - Journal of Materials …, 2025 - Elsevier
The rising prevalence of drug-resistant Gram-positive pathogens, particularly methicillin-
resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) …