Aging is a major risk factor for many diseases including metabolic syndrome, cancer,
inflammation, and neurodegeneration. Identifying mechanistic common denominators …

Proper nutrition is crucial for normal brain and neurocognitive development. Failure to
optimize neurodevelopment early in life can have profound long-term implications for both …

An important tenet of learning and memory is the notion of a molecular switch that promotes
the formation of long-term memory,,–. The regulation of proteostasis is a critical and rate …

Unraveling the molecular mechanisms governing long-term synaptic plasticity is a key to
understanding how the brain stores information in neural circuits and adapts to a changing …

The amount and availability of proteins are regulated by their synthesis, degradation, and
transport. These processes can specifically, locally, and temporally regulate a protein or a …

Accumulating evidence shows that metformin is an insulin-sensitizing antidiabetic drug
widely used in the treatment of type 2 diabetes mellitus (T2DM), which can exert favorable …

BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the
dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we …

Neurons in the insular cortex are activated by acute and chronic pain, and inhibition of
neuronal activity in the insular cortex has analgesic effects. We found that in a mouse model …

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of four known
kinases that respond to cellular stress by deactivating the eukaryotic initiation factor 2 α …

The eukaryotic translation initiation factor (eIF) 4E, which binds to the 5'-cap of mRNA,
undergoes phosphorylation on a single conserved serine, executed by the mitogen …