Subclinical thyroid disease (SCTD) is defined as serum free T4 and free T3 levels within
their respective reference ranges in the presence of abnormal serum TSH levels. SCTD is …

Context: Measurements from all age groups defined the upper limit of the TSH reference
range in National Health and Nutrition Examination Survey III. The TSH median, 97.5 centile …

Context: TSH is a known thyroid growth factor, but the pathogenic role of TSH in thyroid
oncogenesis is unclear. Objective: The aim was to examine the relationship between …

Context Levothyroxine monotherapy is the treatment of choice for hypothyroid patients
because peripheral T4 to T3 conversion is believed to account for the overall tissue …

Background: The use of age-and ethnicity-specific thyrotropin (TSH) reference limits
decreases misclassification of patients with thyroid dysfunction. Developing such limits …

Background: Establishing the reference interval for thyrotropin (TSH) and free thyroxine (T4)
is clinically important because a number of disease states have been linked to alterations in …

Context: TSH reference limits, particularly the upper limit, are controversial. The traditional
and prevailing method for setting limits uses TSH distribution of thyroid disease-free …

Context: Studies of long-term outcomes of subclinical hypothyroidism have assessed only
baseline thyroid function, despite natural transitions to euthyroidism and overt …

Context: Longitudinal studies of risk factors for hypothyroidism are required to inform debate
regarding the TSH reference range. There are limited longitudinal data on the predictive …

Context: Data on thyroid function in the oldest old are sparse, and existing studies show
conflicting evidence on the relationship between thyroid function and mortality in this age …