Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

For half a century, we have known that some patients experience neurocognitive dysfunction
after cardiac surgery, yet defining its incidence, course, and causes remains challenging …

Anticholinergic and sedative medications are commonly used in older adults and are
associated with adverse clinical outcomes. The Drug Burden Index was developed to …

Population aging is accelerating rapidly worldwide with increasing numbers of elderly
patients being admitted to ICUs. In the USA elderly patients currently account for 42–52% of …

The neurotransmitter histamine receives less attention compared with other biogenic
amines, because of its moderate action in the central nervous system (CNS). However …

Histamine in the brain is produced by a group of tuberomamillary neurons in the posterior
hypothalamus and a limited number of mast cells in different parts of the brain. Four G …

Purpose To evaluate the performance of delirium‐identification algorithms in administrative
claims and drug utilization data. Methods We used data from a prospective study of 184 …

Background Benzodiazepine use is associated with adverse drug events and higher
mortality. Known risk factors for benzodiazepine-related adverse events include lung …

Background Non-specific symptoms, such as confusion, are often suspected to be caused
by urinary tract infection (UTI) and continues to be the most common reason for suspecting a …

Background With an ageing population, the demand for joint arthroplasties and the burden
of postoperative delirium is likely to increase. Given the lack of large-scale data, we …