Tumor cellular metabolism exhibits distinguishing features that collectively enhance
biomass synthesis while maintaining redox balance and cellular homeostasis. These …

Cancer remains the second leading cause of mortality worldwide. In the course of this
multistage and multifactorial disease, a set of alterations takes place, with genetic and …

The circadian clock confers daily rhythmicity to many crucial biological processes and
behaviors and its disruption is closely associated with carcinogenesis in several types of …

Tumour‐associated macrophages (TAMs) abundantly infiltrate high‐grade gliomas and
orchestrate immune response, but their diversity in isocitrate dehydrogenase (IDH) …

Mitophagy, which selectively eliminates the dysfunctional and excess mitochondria by
autophagy, is crucial for cellular homeostasis under stresses such as hypoxia. Dysregulation …

Sunitinib resistance is a major challenge in systemic therapy for renal cell carcinoma (RCC).
The role of circular RNAs (circRNAs) in regulating sunitinib resistance of RCC is largely …

Background The investigation of lncRNAs has provided a novel perspective for elucidating
mechanisms underlying diverse physiological and pathological processes. Compelling …

Simple Summary Diacylglycerol (DG) kinase (DGK) phosphorylates DG to generate
phosphatidic acid (PA). DGKα is highly expressed in several refractory cancer cells …

Background Intrinsic or acquired resistance to HER2-targeted therapy is often a problem
when small molecule tyrosine kinase inhibitors or antibodies are used to treat patients with …

High-dose dexamethasone (DEX) is used to treat chemotherapy-induced nausea and
vomiting or to control immunotherapy-related autoimmune diseases in clinical practice …