Metal ions, especially redox active copper, are thought to play critical roles in
neurodegenerative disorders. As a matter of fact, metal binding may result into severe …

There are numerous neurodegenerative diseases but Alzheimer's disease and Parkinson's
disease are the most common. In contrast, prion diseases are very rare but have sparked …

The prion protein (PrPC) is implicated in the spongiform encephalopathies in mammals, and
it is known to bind Cu (II) at the N-terminal region. The region around His111 has been …

The prion protein (PrP) is a Cu2+-binding cell-surface glycoprotein. Using various PrP
fragments and spectroscopic techniques, we show that two Cu2+ ions bind to a region …

Copper is an essential nutrient for the normal development of the brain and nervous system,
although the hallmark of several neurological diseases is a change in copper concentrations …

Human prion protein (hPrP) fragments encompassing the 91–120 region, namely hPrP92–
100 (SP1), hPrP106–113 (SP2), hPrP91–120 (LP1), and hPrP91–114 (LP2), were …

The cellular prion protein (PrPC) has emerged as an important copper binding protein. The
interaction of copper with PrPC may play important roles in both the physiological function of …

The ability of the cellular prion protein (PrPC) to bind copper in vivo points to a physiological
role for PrPC in copper transport. Six copper binding sites have been identified in the …

Many neurodegenerative disorders are induced by protein conformational change. Prion
diseases are characterized by protein conformational conversion from a normal cellular form …

Among the common features shared by neurodegenerative diseases there is the central role
played by specific proteins or peptides which accumulate in neurons as insoluble plaques or …