The Caenorhabditis elegans genome possesses homologs of about two-thirds of all human
disease genes. Based on its physiological aging characteristics and superiority, the use of …

Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

Caenorhabditis elegans is an exceptionally valuable model for aging research because of
many advantages, including its genetic tractability, short lifespan, and clear age‐dependent …

Aging animals display a broad range of progressive degenerative changes, and one of the
most fascinating is the decline of female reproductive function. In the model organism …

Mitochondrial dysfunction is a hallmark of skeletal muscle degeneration during aging. One
mechanism through which mitochondrial dysfunction can be caused is through changes in …

Abstract Nuclear factor (erythroid-derived 2)-like 2 and its Caenorhabditis elegans ortholog,
SKN-1, are transcription factors that have a pivotal role in the oxidative stress response …

Pheromones exchanged by conspecifics are a major class of chemical signals that can alter
behavior, physiology, and development. In particular, males and females communicate with …

Although many genetic factors and lifestyle interventions are known to affect the mean
lifespan of animal populations, the physiological variation displayed by individuals across …

A wealth of knowledge on the genetic mechanisms that govern aging has emerged from the
study of mutants that exhibit enhanced longevity and exceptional resilience to adverse …

ABSTRACT A major factor driving stem cell decline is stem cell niche aging, but its
molecular mechanism remains elusive. We use the Caenorhabditis elegans distal tip cell …