Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS

C Wyart, M Carbo-Tano, Y Cantaut-Belarif… - Nature Reviews …, 2023 - nature.com
The cerebrospinal fluid (CSF) is a complex solution that circulates around the CNS, and
whose composition changes as a function of an animal's physiological state. Ciliated …

Spinal cord transcutaneous stimulation in cervical spinal cord injury: A review examining upper extremity neuromotor control, recovery mechanisms, and future …

G Singh, P Sharma, G Forrest, S Harkema… - Journal of …, 2024 - liebertpub.com
Cervical spinal cord injury (SCI) results in significant sensorimotor impairments below the
injury level, notably in the upper extremities (UEs), impacting daily activities and quality of …

Presynaptic gating of monkey proprioceptive signals for proper motor action

S Tomatsu, GH Kim, S Kubota, K Seki - Nature Communications, 2023 - nature.com
Our rich behavioural repertoire is supported by complicated synaptic connectivity in the
central nervous system, which must be modulated to prevent behavioural control from being …

Muscle spasms after spinal cord injury stem from changes in motoneuron excitability and synaptic inhibition, not synaptic excitation

A Mahrous, D Birch, CJ Heckman… - Journal of …, 2024 - Soc Neuroscience
Muscle spasms are common in chronic spinal cord injury (SCI), posing challenges to
rehabilitation and daily activities. Pharmacological management of spasms mostly targets …

Poststroke arm and hand paresis: should we target the cervical spinal cord?

E Pirondini, E Carranza, JM Balaguer, E Sorensen… - Trends in …, 2022 - cell.com
Despite advances in understanding of corticospinal motor control and stroke
pathophysiology, current rehabilitation therapies for poststroke upper limb paresis have …

Facilitation of sensory transmission to motoneurons during cortical or sensory‐evoked primary afferent depolarization (PAD) in humans

K Metz, IC Matos, Y Li, B Afsharipour… - The Journal of …, 2023 - Wiley Online Library
Sensory and corticospinal tract (CST) pathways activate spinal GABAergic interneurons that
have axoaxonic connections onto proprioceptive (Ia) afferents that cause long‐lasting …

Biophysics of frequency-dependent variation in paresthesia and pain relief during spinal cord stimulation

ER Rogers, M Capogrosso, SF Lempka - Journal of Neuroscience, 2024 - jneurosci.org
The neurophysiological effects of spinal cord stimulation (SCS) for chronic pain are poorly
understood, resulting in inefficient failure-prone programming protocols and inadequate …

The plasticity of nerve fibers: The prolonged effects of polarization of afferent fibers

E Jankowska, I Hammar - Journal of Neurophysiology, 2021 - journals.physiology.org
The review surveys various aspects of the plasticity of nerve fibers, in particular the
prolonged increase in their excitability evoked by polarization, focusing on a long-lasting …

Testing spasticity mechanisms in chronic stroke before and after intervention with contralesional motor cortex 1 Hz rTMS and physiotherapy

W Mahmoud, H Hultborn, J Zuluaga, C Zrenner… - Journal of …, 2023 - Springer
Background Previous studies showed that repetitive transcranial magnetic stimulation
(rTMS) reduces spasticity after stroke. However, clinical assessments like the modified …

Post‐activation depression from primary afferent depolarization (PAD) produces extensor H‐reflex suppression following flexor afferent conditioning

K Metz, IC Matos, K Hari, O Bseis… - The Journal of …, 2023 - Wiley Online Library
Suppression of the extensor H‐reflex by flexor afferent conditioning is thought to be
produced by a long‐lasting inhibition of extensor Ia afferent terminals via GABAA receptor …