Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS
The cerebrospinal fluid (CSF) is a complex solution that circulates around the CNS, and
whose composition changes as a function of an animal's physiological state. Ciliated …
whose composition changes as a function of an animal's physiological state. Ciliated …
Spinal cord transcutaneous stimulation in cervical spinal cord injury: A review examining upper extremity neuromotor control, recovery mechanisms, and future …
Cervical spinal cord injury (SCI) results in significant sensorimotor impairments below the
injury level, notably in the upper extremities (UEs), impacting daily activities and quality of …
injury level, notably in the upper extremities (UEs), impacting daily activities and quality of …
Presynaptic gating of monkey proprioceptive signals for proper motor action
S Tomatsu, GH Kim, S Kubota, K Seki - Nature Communications, 2023 - nature.com
Our rich behavioural repertoire is supported by complicated synaptic connectivity in the
central nervous system, which must be modulated to prevent behavioural control from being …
central nervous system, which must be modulated to prevent behavioural control from being …
Muscle spasms after spinal cord injury stem from changes in motoneuron excitability and synaptic inhibition, not synaptic excitation
A Mahrous, D Birch, CJ Heckman… - Journal of …, 2024 - Soc Neuroscience
Muscle spasms are common in chronic spinal cord injury (SCI), posing challenges to
rehabilitation and daily activities. Pharmacological management of spasms mostly targets …
rehabilitation and daily activities. Pharmacological management of spasms mostly targets …
Facilitation of sensory transmission to motoneurons during cortical or sensory‐evoked primary afferent depolarization (PAD) in humans
K Metz, IC Matos, Y Li, B Afsharipour… - The Journal of …, 2023 - Wiley Online Library
Sensory and corticospinal tract (CST) pathways activate spinal GABAergic interneurons that
have axoaxonic connections onto proprioceptive (Ia) afferents that cause long‐lasting …
have axoaxonic connections onto proprioceptive (Ia) afferents that cause long‐lasting …
Biophysics of frequency-dependent variation in paresthesia and pain relief during spinal cord stimulation
The neurophysiological effects of spinal cord stimulation (SCS) for chronic pain are poorly
understood, resulting in inefficient failure-prone programming protocols and inadequate …
understood, resulting in inefficient failure-prone programming protocols and inadequate …
Testing spasticity mechanisms in chronic stroke before and after intervention with contralesional motor cortex 1 Hz rTMS and physiotherapy
Background Previous studies showed that repetitive transcranial magnetic stimulation
(rTMS) reduces spasticity after stroke. However, clinical assessments like the modified …
(rTMS) reduces spasticity after stroke. However, clinical assessments like the modified …
Post‐activation depression from primary afferent depolarization (PAD) produces extensor H‐reflex suppression following flexor afferent conditioning
Suppression of the extensor H‐reflex by flexor afferent conditioning is thought to be
produced by a long‐lasting inhibition of extensor Ia afferent terminals via GABAA receptor …
produced by a long‐lasting inhibition of extensor Ia afferent terminals via GABAA receptor …
Locomotor-related propriospinal V3 neurons produce primary afferent depolarization and modulate sensory transmission to motoneurons
When a muscle is stretched, sensory feedback not only causes reflexes but also leads to a
depolarization of sensory afferents throughout the spinal cord (primary afferent …
depolarization of sensory afferents throughout the spinal cord (primary afferent …
Modulation of sensory input to the spinal cord: Contribution of focal epidural polarization and of GABA released by interneurons and glial cells
I Hammar, E Jankowska - European Journal of Neuroscience, 2024 - Wiley Online Library
Modulation of input from primary afferent fibres has long been examined at the level of the
first relays of these fibres. However, recent studies reveal that input to the spinal cord may …
first relays of these fibres. However, recent studies reveal that input to the spinal cord may …