Pancreatic stellate cells (PSCs) and cancer-associated fibroblasts (CAFs) are highly
abundant cells in the pancreatic tumor microenvironment (TME) that modulate desmoplasia …

Tumours are heterogeneous tissues containing diverse populations of cells and an
abundant extracellular matrix (ECM). This tumour microenvironment prompts cancer cells to …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a poor
prognosis, largely due to its unique tumor microenvironment (TME) and dense fibrotic …

Fibroblasts are among the most common cell types in the stroma responsible for creating
and maintaining the structural organization of the extracellular matrix in the dermis, skin …

This comprehensive review delves into the complex interplay between mitochondrial gene
defects and pancreatic cancer pathogenesis through a multiomics approach. By …

Neoadjuvant chemotherapy (NAT) is increasingly used for the treatment of non‐metastatic
pancreatic ductal adenocarcinoma (PDAC) and is established as a standard of care for …

Pancreatic ductal adenocarcinoma (PDAC) is a solid-tumor malignancy. To enhance the
treatment landscape of PDAC, a 3D model optimized for rigorous drug screening is …

Cellular proliferation, function and survival is reliant upon maintaining appropriate
intracellular polyamine levels. Due to increased metabolic needs, cancer cells elevate their …

Cancer-associated fibroblasts (CAFs) often form a major component of the tumor
microenvironment (TMA), providing conditions for cancer cells to thrive. CAFs may contribute …

Pancreatic ductal adenocarcinoma (PDAC), the fourteenth most common malignancy, is a
major contributor to cancer-related death with the utmost case fatality rate among all …