Alzheimer's Disease (AD) is the major form of senile dementia, characterized by neuronal
loss, extracellular deposits, and neurofibrillary tangles. It is accompanied by a loss of …

Wnts comprise a large family of proteins that have shown to be part of a signaling cascade
that regulates several aspects of development including organogenesis, midbrain …

Alzheimer's disease (AD) is one of the major disabling and lethal diseases for aged
individuals worldwide. To date, there are more than 10 hypotheses proposed for AD …

In Alzheimer's disease (AD) basic research and drug discovery, mouse models are essential
resources for uncovering biological mechanisms, validating molecular targets and screening …

A lzheimer's disease (AD) is a neurodegenerative disorder characterized by loss of memory
and cognitive abilities, and the appearance of amyloid plaques composed of the amyloid‐β …

The aims of this review are: 1) to describe which cholinergic neurons are affected in brain
neurodegenerative diseases leading to dementia; 2) to discuss the possible causes of the …

Wnt signaling function starts during the development of the nervous system and is crucial for
synaptic plasticity in the adult brain. Clearly Wnt effects in synaptic and plastic processes are …

Accumulating evidence indicates that abnormal deposition of amyloid‐β (Aβ) peptide in the
brain is responsible for endothelial cell damage and consequently leads to blood–brain …

Progress in the fields of neuroscience and molecular biology has identified the forebrain
cholinergic system as being important in many higher order brain functions. Further analysis …

Communication between cells occurs through secreted molecules, among which Wnt
ligands play a critical role in balancing cell proliferation, differentiation and cellular …