The role of molecular chaperones in virus infection and implications for understanding and treating COVID-19

L Paladino, AM Vitale, C Caruso Bavisotto… - Journal of clinical …, 2020 - mdpi.com
The COVID-19 pandemic made imperative the search for means to end it, which requires a
knowledge of the mechanisms underpinning the multiplication and spread of its cause, the …

Mechanism and complex roles of HSC70 in viral infections

Z Wang, Y Li, X Yang, J Zhao, Y Cheng… - Frontiers in …, 2020 - frontiersin.org
Heat shock cognate 71-kDa protein (HSC70), a constitutively expressed molecular
chaperon within the heat shock protein 70 family, plays crucial roles in maintaining cellular …

HSP70 and Its Cochaperone CPIP Promote Potyvirus Infection in Nicotiana benthamiana by Regulating Viral Coat Protein Functions

A Hafrén, D Hofius, G Rönnholm, U Sonnewald… - The Plant …, 2010 - academic.oup.com
This study demonstrates that heat shock protein 70 (HSP70) together with its cochaperone
CPIP regulates the function of a potyviral coat protein (CP), which in turn can interfere with …

Topical Spray of dsRNA Induces Mortality and Inhibits Chilli Leaf Curl Virus Transmission by Bemisia tabaci Asia II 1

P Chakraborty, A Ghosh - Cells, 2022 - mdpi.com
Chilli leaf curl virus (ChiLCV; genus: Begomovirus), transmitted by Bemisia tabaci
(Gennadius)(Hemiptera: Aleyrodidae) in a persistent-circulative manner, is a major …

Virus-mediated compartmentalization of the host translational machinery

EA Desmet, LJ Anguish, JSL Parker - MBio, 2014 - Am Soc Microbiol
Viruses require the host translational apparatus to synthesize viral proteins. Host stress
response mechanisms that suppress translation, therefore, represent a significant obstacle …

Differential roles of Hsp70 and Hsp90 in the assembly of the replicase complex of a positive-strand RNA plant virus

A Mine, K Hyodo, Y Tajima, K Kusumanegara… - Journal of …, 2012 - Am Soc Microbiol
Assembly of viral replicase complexes of eukaryotic positive-strand RNA viruses is a
regulated process: multiple viral and host components must be assembled on intracellular …

Recruitment of the Host Plant Heat Shock Protein 70 by Tomato Yellow Leaf Curl Virus Coat Protein Is Required for Virus Infection

R Gorovits, A Moshe, M Ghanim, H Czosnek - PloS one, 2013 - journals.plos.org
A functional capsid protein (CP) is essential for host plant infection and insect transmission
of Tomato yellow leaf curl virus (TYLCV) and other monopartite begomoviruses. We have …

Peptides released from reovirus outer capsid form membrane pores that recruit virus particles

T Ivanovic, MA Agosto, L Zhang, K Chandran… - The EMBO …, 2008 - embopress.org
Nonenveloped animal viruses must disrupt or perforate a cell membrane during entry.
Recent work with reovirus has shown formation of size‐selective pores in RBC membranes …

From touchdown to transcription: the reovirus cell entry pathway

P Danthi, KM Guglielmi, E Kirchner, B Mainou… - Cell entry by non …, 2010 - Springer
Mammalian orthoreoviruses (reoviruses) are prototype members of the Reoviridae family of
nonenveloped viruses. Reoviruses contain ten double-stranded RNA gene segments …

Proteostasis in viral infection: unfolding the complex virus–chaperone interplay

R Aviner, J Frydman - Cold Spring Harbor Perspectives …, 2020 - cshperspectives.cshlp.org
Viruses are obligate intracellular parasites that rely on their hosts for protein synthesis,
genome replication, and viral particle production. As such, they have evolved mechanisms …