Signaling by antibodies: recent progress
IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity
through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed …
through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed …
Ig constant region effects on variable region structure and function
A Janda, A Bowen, NS Greenspan… - Frontiers in …, 2016 - frontiersin.org
The adaptive humoral immune response is responsible for the generation of antimicrobial
proteins known as immunoglobulin molecules or antibodies. Immunoglobulins provide a …
proteins known as immunoglobulin molecules or antibodies. Immunoglobulins provide a …
Detection of individual proteins bound along DNA using solid-state nanopores
DNA in cells is heavily covered with all types of proteins that regulate its genetic activity.
Detection of DNA-bound proteins is a challenge that is well suited to solid-state nanopores …
Detection of DNA-bound proteins is a challenge that is well suited to solid-state nanopores …
Broadly neutralizing anti-influenza virus antibodies: enhancement of neutralizing potency in polyclonal mixtures and IgA backbones
W He, CE Mullarkey, JA Duty, TM Moran… - Journal of …, 2015 - Am Soc Microbiol
Current influenza virus vaccines rely upon the accurate prediction of circulating virus strains
months in advance of the actual influenza season in order to allow time for vaccine …
months in advance of the actual influenza season in order to allow time for vaccine …
IgG cooperativity–Is there allostery? Implications for antibody functions and therapeutic antibody development
ABSTRACT A central dogma in immunology is that an antibody's in vivo functionality is
mediated by 2 independent events: antigen binding by the variable (V) region, followed by …
mediated by 2 independent events: antigen binding by the variable (V) region, followed by …
[PDF][PDF] In-depth analysis of subclass-specific conformational preferences of IgG antibodies
X Tian, B Vestergaard, M Thorolfsson, Z Yang… - IUCrJ, 2015 - journals.iucr.org
IgG subclass-specific differences in biological function and in vitro stability are often referred
to variations in the conformational flexibility, while this flexibility has rarely been …
to variations in the conformational flexibility, while this flexibility has rarely been …
Dynamic views of the Fc region of immunoglobulin G provided by experimental and computational observations
The Fc portion of immunoglobulin G (IgG) is a horseshoe-shaped homodimer, which
interacts with various effector proteins, including Fcγ receptors (FcγRs). These interactions …
interacts with various effector proteins, including Fcγ receptors (FcγRs). These interactions …
A monoclonal antibody to Cryptococcus neoformans glucuronoxylomannan manifests hydrolytic activity for both peptides and polysaccharides
Studies in the 1980s first showed that some natural antibodies were" catalytic" and able to
hydrolyze peptide or phosphodiester bonds in antigens. Many naturally occurring catalytic …
hydrolyze peptide or phosphodiester bonds in antigens. Many naturally occurring catalytic …
Monoclonal antibodies follow distinct aggregation pathways during production-relevant acidic incubation and neutralization
Purpose Aggregation aspects of therapeutic monoclonal antibodies (mAbs) are of common
concern to the pharmaceutical industry. Low pH treatment is applied during affinity …
concern to the pharmaceutical industry. Low pH treatment is applied during affinity …
Characterization and optimization of heroin hapten-BSA conjugates: method development for the synthesis of reproducible hapten-based vaccines
A potential new treatment for drug addiction is immunization with vaccines that induce
antibodies that can abrogate the addictive effects of the drug of abuse. One of the …
antibodies that can abrogate the addictive effects of the drug of abuse. One of the …