The paradoxical role of cellular senescence in cancer

J Yang, M Liu, D Hong, M Zeng… - Frontiers in cell and …, 2021 - frontiersin.org
Cellular senescence occurs in proliferating cells as a consequence of various triggers
including telomere shortening, DNA damage, and inappropriate expression of oncogenes …

Lipids as regulators of cellular senescence

S Hamsanathan, AU Gurkar - Frontiers in physiology, 2022 - frontiersin.org
Lipids are key macromolecules that perform a multitude of biological functions ranging from
maintaining structural integrity of membranes, energy storage, to signaling molecules …

[HTML][HTML] Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis

CD Wiley, R Sharma, SS Davis, JA Lopez-Dominguez… - Cell metabolism, 2021 - cell.com
Cellular senescence is a stress or damage response that causes a permanent proliferative
arrest and secretion of numerous factors with potent biological activities. This senescence …

Lipids and Lipid Metabolism in Cellular Senescence: Emerging Targets for Age-Related Diseases

Q Zeng, YZ Gong, N Zhu, YN Shi, CJ Zhang… - Ageing Research …, 2024 - Elsevier
Cellular senescence is a kind of cellular state triggered by endogenous or exogenous
stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence …

The role of endothelial lipase in lipid metabolism, inflammation, and cancer

EY Justine, SY Han, B Wolfson… - Histology and …, 2017 - pmc.ncbi.nlm.nih.gov
Endothelial lipase (LIPG) plays a critical role in lipoprotein metabolism, cytokine expression,
and the lipid composition of cells. Thus far, the extensive investigations of LIPG have …

LIPG‐promoted lipid storage mediates adaptation to oxidative stress in breast cancer

C Cadenas, S Vosbeck, K Edlund… - … journal of cancer, 2019 - Wiley Online Library
Endothelial lipase (LIPG) is a cell surface associated lipase that displays phospholipase A1
activity towards phosphatidylcholine present in high‐density lipoproteins (HDL). LIPG was …

LIPG signaling promotes tumor initiation and metastasis of human basal-like triple-negative breast cancer

PK Lo, Y Yao, JS Lee, Y Zhang, W Huang, MA Kane… - Elife, 2018 - elifesciences.org
Current understanding of aggressive human basal-like triple-negative breast cancer (TNBC)
remains incomplete. In this study, we show endothelial lipase (LIPG) is aberrantly …

Transcriptomic and physiological analyses of hepatopancreas reveal the key metabolic changes in response to dietary copper level in Pacific white shrimp …

B Shi, Y Yuan, M Jin, MB Betancor, DR Tocher, L Jiao… - Aquaculture, 2021 - Elsevier
All living organisms require copper for growth and development, but the gene expression
profiles and molecular mechanisms underpinning dietary copper are poorly investigated …

Non-targeted serum lipidomics analysis and potential biomarkers of laryngeal cancer based on UHPLC-QTOF-MS

H Wang, Y Luo, H Chen, H Hou, Q Hu, M Ji - Metabolites, 2022 - mdpi.com
Laryngeal cancer is a common head and neck malignant cancer type. However, effective
biomarkers for diagnosis are lacking and pathogenesis is unclear. Lipidomics is a powerful …

Lipids and the hallmarks of ageing: from pathology to interventions

R Sharma, B Diwan - Mechanisms of Ageing and Development, 2023 - Elsevier
Lipids are critical structural and functional architects of cellular homeostasis. Change in
systemic lipid profile is a clinical indicator of underlying metabolic pathologies, and …