Colorectal cancer (CRC), a multifactorial disease, is usually induced and developed through
complex mechanisms, including impact of diet and lifestyle, genomic abnormalities, change …

The peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is a
central modulator of cell metabolism. It regulates mitochondrial biogenesis and oxidative …

Cancer cells display an altered energy metabolism, which was proposed to be the root of
cancer. This early discovery was done by O. Warburg who conducted one of the first studies …

Radiotherapy is a major component of standard-of-care treatment for gliomas, the most
prevalent type of brain tumor. However, resistance to radiotherapy remains a major concern …

In recent years, because of improved cancer screening, detection and treatment modalities,
a rapid increase in the population of colorectal and other cancer survivors has been …

Colon cancer is one of the most malignant cancers worldwide. Nearly 20% of all colon
cancer patients are diagnosed at stage IV (metastasis). However, further study of colon …

Epidemiologic evidence suggests that obesity and sedentary are modifiable factors strongly
associated with breast cancer risk worldwide. Since breast cancer represents the most …

Significance: Mitochondria are recognized as a central metabolic hub with bioenergetic,
biosynthetic, and signaling functions that tightly control key cellular processes. As a crucial …

This article reviews the synergistic effects of antioxidant-enriched functional foods and
exercise in improving metabolic health, focusing on the underlying molecular mechanisms …

PGC-1α controls, to a large extent, the capacity of cells to respond to changing nutritional
requirements and energetic demands. The key role of metabolic reprogramming in tumor …