An adagio for viruses, played out on ancient DNA

T de-Dios, CL Scheib… - Genome Biology and …, 2023 - academic.oup.com
Studies of ancient DNA have transformed our understanding of human evolution.
Paleogenomics can also reveal historic and prehistoric agents of disease, including …

Unmasking the tissue-resident eukaryotic DNA virome in humans

L Pyöriä, D Pratas, M Toppinen, K Hedman… - Nucleic Acids …, 2023 - academic.oup.com
Little is known on the landscape of viruses that reside within our cells, nor on the interplay
with the host imperative for their persistence. Yet, a lifetime of interactions conceivably have …

Infectious disease in the Pleistocene: Old friends or old foes?

CJ Houldcroft, S Underdown - American Journal of Biological …, 2023 - Wiley Online Library
The impact of endemic and epidemic disease on humans has traditionally been seen as a
comparatively recent historical phenomenon associated with the Neolithisation of human …

Efficient DNA sequence compression with neural networks

M Silva, D Pratas, AJ Pinho - GigaScience, 2020 - academic.oup.com
Background The increasing production of genomic data has led to an intensified need for
models that can cope efficiently with the lossless compression of DNA sequences. Important …

Reactivation of a transplant recipient's inherited human herpesvirus 6 and implications to the graft

L Hannolainen, L Pyöriä, D Pratas, J Lohi… - The Journal of …, 2024 - academic.oup.com
Background The implications of inherited chromosomally integrated human herpesvirus 6
(iciHHV-6) in solid organ transplantation remain uncertain. Although this trait has been …

Characterization of the human blood virome in Iranian multiple transfused patients

M Thijssen, G Khamisipour, M Maleki, T Devos, G Li… - Viruses, 2023 - mdpi.com
Blood transfusion safety is an essential element of public health. Current blood screening
strategies rely on targeted techniques that could miss unknown or unexpected pathogens …

The epidemiological and genetic characteristics of human parvovirus B19 in patients with febrile rash illnesses in China

H Jiang, Q Qiu, Y Zhou, Y Zhang, W Xu, A Cui, X Li - Scientific Reports, 2023 - nature.com
To understand the epidemiological and genetic characteristics of B19V, a multiple-province
surveillance of patients with febrile rash illnesses (FRIs) were conducted in China during …

The complexity landscape of viral genomes

JM Silva, D Pratas, T Caetano, S Matos - GigaScience, 2022 - academic.oup.com
Background Viruses are among the shortest yet highly abundant species that harbor
minimal instructions to infect cells, adapt, multiply, and exist. However, with the current …

Torque Teno virus primary infection Kinetics in early childhood

E Väisänen, I Kuisma, M Mäkinen, J Ilonen, R Veijola… - Viruses, 2022 - mdpi.com
Human torque teno viruses (TTVs) are a diverse group of small nonenveloped viruses with
circular, single-stranded DNA genomes. These elusive anelloviruses are harbored in the …

The human bone marrow is host to the DNAs of several viruses

M Toppinen, A Sajantila, D Pratas… - Frontiers in cellular …, 2021 - frontiersin.org
The long-term impact of viruses residing in the human bone marrow (BM) remains
unexplored. However, chronic inflammatory processes driven by single or multiple viruses …