Introduction Immune-checkpoint inhibitors (ICIs) have emerged as a core pillar of cancer
therapy as single agents or in combination regimens both in adults and children …

The extracellular matrix is a network of secreted macromolecules that provides a
harmonious meshwork for the growth and homeostatic development of organisms. It …

Multimerin-2 is an extracellular matrix glycoprotein and member of the elastin microfibril
interface-located (EMILIN) family of proteins. Multimerin-2 is deposited along blood vessels …

Angiogenesis, the formation of the new blood vessels from pre-existing vasculature, is an
essential process occurring under both normal and pathological conditions, such as …

The use of immune checkpoint inhibitors has revolutionized the treatment of melanoma
patients, leading to remarkable improvements in the cure. However, to ensure a safe and …

The extracellular matrix (ECM) is a major constituent of the tumor microenvironment, acting
as a mediator that supports the progression of gastrointestinal (GI) cancers, particularly in …

Abstract Multimerin-1 (MMRN1) is a platelet protein with a role in haemostasis and
coagulation. It is also present in endothelial cells (ECs) and the extracellular matrix (ECM) …

Gastrointestinal tumors are responsible for more cancer-related fatalities than any other type
of tumors, and colorectal and gastric malignancies account for a large part of these …

Gastric cancer is a frequent human tumor and often a lethal disease. Targeted therapy for
gastric carcinomas is far behind vis-à-vis other solid tumors, primarily because of the paucity …

Purpose: The purpose of this study was to investigate the involvement of CD93 and
Multimerin-2 in three choroidal neovascularization (CNV) models and to evaluate their …