The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

Creatine (Cr) is a ubiquitous molecule that is synthesized mainly in the liver, kidneys, and
pancreas. Most of the Cr pool is found in tissues with high-energy demands. Cr enters target …

During the last decades a considerable amount of research has been focused on cancer.
Recently, tumor cell metabolism has been considered as a possible target for cancer …

Dysfunction of cardiac energy metabolism plays a critical role in many cardiac diseases,
including heart failure, myocardial infarction and ischemia–reperfusion injury and organ …

In living cells, growth is the result of coupling between substrate catabolism and multiple
metabolic processes that take place during net biomass formation and maintenance …

Mitochondria regulate critical components of cellular function via ATP production, reactive
oxygen species production, Ca2+ handling and apoptotic signaling. Two classical methods …

Mitochondrial oxidative phosphorylation (OXPHOS) sustains organelle function and plays a
central role in cellular energy metabolism. The OXPHOS system consists of 5 multisubunit …

VDAC1 is found at the crossroads of metabolic and survival pathways. VDAC1 controls
metabolic cross-talk between mitochondria and the rest of the cell by allowing the influx and …

Mitochondria are complex organelles constantly undergoing processes of fusion and fission,
processes that not only modulate their morphology, but also their function. Yet the …

Regulation of mitochondrial physiology requires an efficient exchange of molecules
between mitochondria and the cytoplasm via the outer mitochondrial membrane (OMM). The …